缺血性脑血管病危险因素研究进展
包华;赵秀杰;郑晓明;
摘要(Abstract)：
<正>缺血性脑血管病是指由于各种原因导致的脑血管堵塞,致使脑血管功能障碍,引起相关症状。具有高发病率、高致残率、高复发率和高病死率的特点,严重危害人类的健康和生活。目前在国内外对缺血性脑血管的治疗尚无理想的方法,因此,深入探讨缺血性脑血管病的危险因素并积极干预对降低其发病率、复发率,最终全面降低致残率和病死率具有重要意义。缺血性脑血管病的危险因素分为已经明确的
关键词(KeyWords)： 缺血性脑血管病;危险因素
基金项目(Foundation):
作者(Authors): 包华;赵秀杰;郑晓明;
参考文献(References)：
- [1]中华医学会神经病学会脑血管病学组卒中一级预防指南撰写组.中国卒中一级预防指南(2010)[J].中华神经科杂志,2011,44:282-284.
- [2]Brattstrom L,Lindgren A,Israelsson B,et al.Hyperhomocys-teinaemia in stroke:prevalence,cause,and relationships to type of stroke and stroke risk factors[J].Eur J Clin Invest,1992,22:214-216.
- [3]Hankey GJ.Is homocysteine a modifiable risk factor for stroke[J].Nat Clin Prac Neuro,l2006,2(1):26-33.
- [4]Kelly PJ,Rosand J,Kistler JP,et al.Homocysteine,MTHFR677C->T polymorphism,and risk of ischemic stroke:results of a meta-analysis[J].Neurology,2002:59(4):529-536.
- [5]罗国刚,韩建峰,王琳,等.血浆同型半胱氨酸与缺血性脑血管病患者颈动脉粥样硬化斑块的关系[J].中国脑血管病杂志,2012,9(3):123-124.
- [6]裴巧玲,王爱枝.高同型半胱氨酸血症与慢性脑缺血关系的相关性分析[J].中国实用神经疾病杂志,2011,14(11):65-66.
- [7]McCully KS.Vascular pathology of homosysteinemia:Implica-tions for the pathogenesis of arteriosclerosi s[J].Am J pahol,1969,56(1):111-128.
- [8]Toole JF,Malinow MR,Chambless LE,et al.Lowening homo-cysteine in patients with ischemic stroke to prevent recurrent stroke,myocardial infaction,and death:the Vitamin Interven-tionfor Stroke Pervention(VISP)randomized conteolled trial[J].JAMA,2001,291:565-575.
- [9]Wang X,Qin X,Demirtas H,et al.Efficacy of folic acid supple-mentation in stroke prevention:a meta-analysis[J].Lancet,2007,369:1876-1882.
- [10]Naghavi M,Libby P,Falk E,et al.From vulnerable plaque to vulnerable patient:a call for new definitions and risk assess-ment strategies:part-I[J].Circulation,2003,108:1664-1672.
- [11]Haffner SM,D’Agostino R,Mykkanen L,et al.Proinsulin and insulin concentrations in relation to carotid wall thickness:In-sulin Resistance Atherosclerosis Study[J].Stroke,1984,15:56-59.
- [12]Sacco RL,Kargman DE,Gu O,et al.Race-ethnicity and deter-minants of intracranial athemsclemtic cerebral infarction.The northern manhattan stroke study[J].Stroke,1995,26(1):14.20.
- [13]Segura T,Serena J,Castellanos M,et al.Embolism in acute middie cerebral artery stenosis[J].Neurology,2001,56:497-501.
- [14]Feldmann E,Daneault N,Kwan E,et al.Chinese-white differ-ences in the distn'bution of occlusive cerebrovascular disease[J].Neurology,1990,40:1541-1545.
- [15]Kurth T,Gaziano JM,Berger K,et al.Body mass index and the risk of stroke in men[J].Arch Intern Med,2002,162(9):2557-2562.
- [16]Isozumi K.Obesity as a risk factor for cerebrovasculardisease[J].Keio J Med,2004,53(1):7-11.
- [17]赵连成,武阳丰,周北凡,等.体质指数与冠心病、脑卒中发病的前瞻性研究[J].中华心血管病杂志,2002,30:430-433.
- [18]Lee CD,Folsom AR,Blair SN.Physical activity and stroke risk:a meta analysis[J].Stroke,2003,34:2475-2481.
- [19]李玉莲.代谢综合征与急性脑血管病相关性研究[S].南昌大学医学院硕士学位论文,2009:1.
- [20]许风雷,热依汗,王力.脑梗死合并代谢综合征的并发症及预后分析[J].2009,12(13):28-29.