唐毅;王冬;陈剑豪;郑伟;郑智楷;

• 1:福建省老年医院福建医科大学教学医院
• 2:武夷山市立医院
• 3:福建省立医院

摘要(Abstract)：

目的探索度洛西汀治疗亚急性带状疱疹神经痛(subacute herpes zoster neuralgia)的临床疗效及安全性。方法 43例病程1个月以上的亚急性带状疱疹神经痛患者,随机分为度洛西汀组(doloxitine group)及对照组(control Group),对照组口服加巴喷丁、普瑞巴林治疗,度洛西汀组在对照组用药的基础上加用度洛西汀治疗;比较治疗前、治疗后1个月及3个月2组疼痛视觉模拟评分法(VAS)、抑郁自评量表(SDS)及焦虑自评量表评分(SAS)、普瑞巴林和加巴喷丁剂量及不良反应。结果度洛西汀组VAS评分较对照组显著降低(P<0.01);2组普瑞巴林剂量无明显变化,而度洛西汀组加巴喷丁剂量较对照组减少(P<0.05);3个月后,加巴喷丁的剂量无显着差异,而普瑞巴林的剂量则显著降低(P<0.05)。抑郁自评量表评分(SDS)、焦虑自评量表评分(SAS)2组无显著性差异;2组不良反应发生率差异无统计学意义(P>0.05)。结论度洛西汀可显著改善带状疱疹后遗神经痛的疗效及生活质量,且临床安全性较好。

关键词(KeyWords)： 度洛西汀;亚急性带状疱疹神经痛;疼痛视觉模拟评分法;抑郁自评量表;焦虑自评量表

Abstract:

Keywords:

基金项目(Foundation): 福建省卫健委中青年骨干人才培养项目(编号:2019-ZQNB-6)

作者(Authors): 唐毅;王冬;陈剑豪;郑伟;郑智楷;

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