叶雪;于润坤;王舒;李记英;赵欣春;

• 1:联勤保障部队天津康复疗养中心

摘要(Abstract)：

目的通过对青年头痛患者完善头CTA检查,探讨偏头痛与Willis环变异的相关性,为治疗策略提供临床依据。方法选择2017-01―2019-12联勤保障部队天津康复疗养中心神经内科头痛门诊就诊的青年头痛患者(病程2～10 a),完善头CTA检查,筛出偏头痛患者80例作为观察组,在其他非偏头痛患者中选择80例作为对照组,统计2组患者中Willis环变异的患病率,同时观察不同变异类型(ACoA缺如或重复、ACA-A1段缺如、PCoA缺如及FTP)的发病率。结果观察组中Willis变异患病率显著高于对照组(P=0.003),其中ACA-A1段缺如发病率显著高于对照组(P=0.004),ACoA变异、PCoA变异及FTP的发病率与对照组比较无明显差异(P>0.05)。二元Logistic回归分析显示,校正偏头痛遗传史的混杂因素,青年偏头痛和Willis变异呈正相关(OR=4.321,95%CI=2.545～7.358,P<0.001)。结论青年偏头痛可能和Willis环变异相关,主要为ACA-A1段变异;Willis环变异可能为青年偏头痛的独立危险因素。

关键词(KeyWords)： 青年;偏头痛;Willis环;变异;相关性

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(编号:81972144)

作者(Authors): 叶雪;于润坤;王舒;李记英;赵欣春;

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