杜家琇;杨冬冬;赵萌;张淑玲;

• 1:郑州人民医院神经内科

摘要(Abstract)：

目的探讨肾素-血管紧张素系统G10631A及C521T基因多态性与脑梗死患病风险的相关性。方法选择2016-05—2019-05郑州人民医院神经内科收治的100例脑梗死患者为脑梗死组,并选择同期100名健康志愿者为对照组。采集2组受试者静脉血样,采用酚/氯仿法提取DNA,采用限制性片段长度多态性分析技术检测G10631A及G521T的单核苷酸多态性。结果脑梗死组患者G10631A的AA基因型及A等位基因频率均高于对照组(χ²=8.672、10.172,P<0.05),脑梗死组患者C521T的TT基因型及T等位基因频率均高于对照组(χ2=8.672、10.172,P<0.05),脑梗死组患者C521T的TT基因型及T等位基因频率均高于对照组(χ²=8.665、22.118,P<0.05),G10631A的AA基因型、C521T的TT基因型可增加脑梗死发生率(OR=2.039、2.031,P<0.05)。脑梗死组患者A-T单体型出现频率高于对照组(χ2=8.665、22.118,P<0.05),G10631A的AA基因型、C521T的TT基因型可增加脑梗死发生率(OR=2.039、2.031,P<0.05)。脑梗死组患者A-T单体型出现频率高于对照组(χ²=16.127,P<0.05),但脑梗死组G-C单体型出现频率低于对照组(χ2=16.127,P<0.05),但脑梗死组G-C单体型出现频率低于对照组(χ²=17.368,P<0.05)。结论肾素-血管紧张素系统G10631A的AA基因型及A等位基因、G521T的TT基因型及T等位基因和A-T单体型可能是脑梗死的遗传易感因素。

关键词(KeyWords)： 肾素-血管紧张素系统;G10631A;C521T;基因多态性;脑梗死

Abstract:

Keywords:

基金项目(Foundation): 河南省科技攻关项目(编号：2018020821)

作者(Authors): 杜家琇;杨冬冬;赵萌;张淑玲;

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