谭西英;王宇;李欣;郭志勇;

• 1:新乡市第一人民医院新乡医学院附属人民医院

摘要(Abstract)：

目的采用氢质子磁共振波谱分析技术(¹H-MRS)测定血糖控制不佳的2型糖尿病患者内囊、丘脑、前额叶白质的生化代谢物的变化,探讨2性糖尿病患者中枢神经损伤的特点。方法选取42例血糖控制不佳的2型糖尿病患者,以40名健康志愿者作为正常对照组,所有入组患者均在入组第2天下午同一时间段完成氢质子磁共振波谱检查,以双侧内囊、丘脑、前额叶为感兴趣脑区,分别检测NAA/Cr值和Cho/Cr值,同日完成双下肢动脉彩超和肌电图检查。结果研究组双侧内囊、双侧丘脑和双侧前额叶白质NAA/Cr值均显著低于对照组,差异有统计学意义(P<0.05);研究组左侧内囊、双侧丘脑和双侧前额叶白质Cho/Cr值均高于对照组,差异有统计学意义(P<0.05);研究组右侧内囊Cho/Cr值与对照组相比差异无统计学意义(P>0.05)。结论血糖控制不佳的2型糖尿病患者可能较早出现中枢神经系统损伤,氢质子波普分析技术有望成为糖尿病中枢神经系统损伤的一种客观检查手段。

关键词(KeyWords)： 磁共振波谱分析技术;2型糖尿病;中枢神经损伤;内囊;丘脑;前额叶

Abstract:

Keywords:

基金项目(Foundation): 2019年度白求恩医学科学研究基金项目(编号:B19173AN)

作者(Authors): 谭西英;王宇;李欣;郭志勇;

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