脑电阻抗监测技术在急性脑梗死患者中的应用进展Progress in the application of brain electrical impedance monitoring technology in patients with acute cerebral infarction
王瑞康;张兵;王巧红;韩冰莎;栗艳茹;冯光;
摘要(Abstract)：
脑电阻抗监测技术是基于生物电阻抗测量的成像技术,其利用生物体液的导电性监测脑部生理、病理状况,产生整个区域的阻抗图或阻抗变化图,具有无创、安全、可实现对脑电阻抗动态、实时监测等优点。脑梗死又称缺血性脑卒中,发病率和病死率高,脑水肿是其常见的致死、致残并发症之一。大面积脑梗死后,脑水肿的发生可导致病死率高达80%。扰动系数作为脑电阻抗的监测指标,它的波动反映颅内水肿的变化,将该技术应用于急性脑梗死患者,可实时判断脑水肿的发生、发展,提高脑梗死早期脑水肿诊断的准确性与治疗的有效性,对改善患者预后有重大意义。
关键词(KeyWords)： 脑电阻抗;急性脑梗死;脑水肿;扰动系数
基金项目(Foundation): 河南省医学科技攻关计划项目(编号：SBGJ2018063)
作者(Authors): 王瑞康;张兵;王巧红;韩冰莎;栗艳茹;冯光;
参考文献(References)：
- [1]BOLING B,KEINATH K.Acute Ischemic Stroke[J].AACN Adv Crit Care,2018,29(2):152-162.DOI:10.4037/aacnacc2018483．
- [2]WU S,WU B,LIU M,et al.Stroke in China:advances and challenges in epidemiology,prevention,and management[J].Lancet,Neurology,2019,18(4):394-405.DOI:10.1016/S1474-4422(18)30500-3．
- [3]LAN J,WU L,TAN X,et al.Application of the cerebral edema monitor on cardiopulmonary bypass in infants[J].Brain Inj,2019,33(10):1379-1384.DOI:10.1080/02699052.2019.1641746．
- [4]ACKMANN J J.Complex bioelectric impedance measurement system for the frequency range from 5 Hz to 1MHz[J].Ann Biomed Eng,1993,21(2):135-146.DOI:10.1007/bf02367609．
- [5]BAYFORD R H.Bioimpedance tomography(electrical impedance tomography)[J].Ann Rev Biomed Eng,2006,8:63-91.DOI:10.1146/annurev.bioeng.8.061505.095716．
- [6]BAYFORD R,TIZZARD A.Bioimpedance imaging:an overview of potential clinical applications[J].Analyst,2012,137(20):4635-4643.DOI:10.1039/c2an35874c．
- [7]XIAO G,LIU G,PENG Y,et al.Study of noninvasive intracranial pressure monitoring by bioelectric impedance method[J].J Biomed Eng,2001,18(1):79-82.DOI:10.1016/j.clnu.2004.06.004．
- [8]ATEFI S R,SEOANE F,LINDECRANTZ K.Electrical Bioimpedance cerebral monitoring.Preliminary results from measurements on stroke patients[J].Ann Conf,2012:126-129.DOI:10.1109/EMBC.2012.6345887．
- [9]COHEN R,ABBOUD S,ARAD M.Monitoring brain damage using bioimpedance technique in a 3Dnumerical model of the head[J].Med Eng Phys,2015,37(5):453-459.DOI:10.1016/j.medengphy.2015.02.011．
- [10]SHI X,YOU F,FU F,et al.Preliminary research on monitoring of cerebral ischemia using electrical impedance tomography technique[J].Ann Conf,2008:1188-1191.DOI:10.1109/IEMBS.2008.4649375．
- [11]LIU L X,DONG W W,WANG J,et al.The role of noninvasive monitoring of cerebral electrical impedance in stroke[J].Acta Neurochirurg,2005,95:137-140.DOI:10.1007/3-211-32318-x_30．
- [12]LIU L,DONG W,JI X,et al.A new method of noninvasive brain-edema monitoring in stroke:cerebral electrical impedance measurement[J].Neurol Res,2006,28(1):31-37.DOI:10.1179/016164106X91843．
- [13]HE L Y,WANG J,LUO Y,et al.Application of noninvasive cerebral electrical impedance measurement on brain edema in patients with cerebral infarction[J].Neurol Res,2010,32(7):770-774.DOI:10.1179/016164109X12478302362572．
- [14]LOU J H,WANG J,LIU L X,et al.Measurement of brain edema by noninvasive cerebral electrical impedance in patients with massive hemispheric cerebral infarction[J].Eur Neurol,2012,68(6):350-357.DOI:10.1159/000342030．
- [15]SONG J,CHEN R,YANG L,et al.Electrical Impedance Changes at Different Phases of Cerebral E-dema in Rats with Ischemic Brain Injury[J].BioMed Res Int,2018:9765174.DOI:10.1155/2018/9765174．
- [16]FU F,LI B,DAI M,et al.Use of electrical impedance tomography to monitor regional cerebral edema during clinical dehydration treatment[J].PloS One,2014,9(12):e113202.DOI:10.1371/journal.pone.0113202．
- [17]NALEPA D,CZARKOWSKA M,ZAUSKA W,et al.Electrical bioimpedance in patients after ischemic stroke,a civilization disease[J].Ann Agric Envir Med,2019,26(1):46-50.DOI:10.26444/aaem/84849．
- [18]TASNEEM N,SAMANIEGO E A,PIEPER C,et al.Brain Multimodality Monitoring:A New Tool in Neurocritical Care of Comatose Patients[J].Crit Care Res Pract,2017:6097265.DOI:10.1155/2017/6097265．
- [19]LINGWOOD B E,DUNSTER K R,COLDITZ P B,et al.Noninvasive measurement of cerebral bioimpedance for detection of cerebral edema in the neonatal piglet[J].Brain Res,2002,945(1):97-105.DOI:10.1016/s0006-8993(02)02744-0．
- [20]CAO L,LI H,FU D,et al.Real-time imaging of infarction deterioration after ischemic stroke in rats using electrical impedance tomography[J].Physiol Meas,2020:10-1088.DOI:10.1088/1361-6579/ab69ba.