李俊敏;彭涛;马兴荣;田田;李京红;王建平;卢宏;

• 1:郑州大学第一附属医院

摘要(Abstract)：

目的分析复发性抗富亮氨酸胶质瘤失活1蛋白(LGI1)脑炎的临床特点、诊断、治疗及预后情况。方法收集郑州大学第一附属医院2015-01—2019-01确诊抗LGI1脑炎患者,回顾性分析复发患者临床表现、实验室及影像检查、治疗及预后。结果 37例抗LGI1脑炎确诊患者中,13例复发,6例有多次复发。4例复发期出现新的症状,9例复发症状为首次发病症状的再次出现。认知功能下降、癫痫、精神症状及自主神经症状为复发患者首次发病和复发常见症状。13例复发患者有10例接受序惯口服激素治疗,第1次复发前口服激素平均时间为2.25个月。13例患者死亡6例。10例患者首次复发重启免疫治疗。预后良好(mRS≤2分)患者复发至重启免疫治疗平均时间2.6 d,预后差患者33.5 d。结论抗LGI1脑炎复发比较常见,患者复发症状多为首次发病症状的再次出现。及时重启免疫治疗的复发患者,预后良好。

关键词(KeyWords)： 自身免疫性脑炎;边缘性脑炎;抗富亮氨酸胶质瘤失活1蛋白;复发

Abstract:

Keywords:

基金项目(Foundation): NSFC-河南联合基金(编号:U1804171)

作者(Authors): 李俊敏;彭涛;马兴荣;田田;李京红;王建平;卢宏;

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