刘丽娇;杨秀丽;徐祥辉;秦毅;

• 1:新乡市第一人民医院神经内科
• 2:新乡医学院第三附属医院

摘要(Abstract)：

目的探讨血清microRNA-124(miR-124)、miR-145检测对急性缺血性脑卒中(AIS)的诊断价值及与颈动脉粥样硬化(CAS)斑块性质的关联性。方法选取新乡市第一人民医院收治的AIS患者82例为AIS组,同期健康体检者82例为对照组。对比2组血清miR-124、miR-145水平及与神经缺损程度的关系,探究AIS发病影响因素及各血清的诊断价值,并检测不同CAS斑块性质患者血清miR-124、miR-145水平,分析二者关联性。结果 AIS组血清miR-124水平低于对照组,miR-145水平高于对照组(P<0.05);重度患者血清miR-124水平低于中度、轻度患者,血清miR-145水平高于中度、轻度患者(P<0.05);血清miR-124、miR-145为AIS发病的重要影响因素(P<0.05);血清miR-145诊断AIS的AUC(0.791)>miR-124(0.717);易损斑块患者血清miR-124低于稳定斑块患者,血清miR-145水平高于稳定斑块患者(P<0.05);血清miR-124水平与神经功能缺损程度、CAS斑块性质呈负相关,血清miR-145水平与神经功能缺损程度、CAS斑块性质呈显著正相关(P<0.05)。结论血清miR-124、miR-145作为诊断AIS的潜在特异性生物标志物,与神经功能缺损程度、CAS斑块性质存在一定相关性,在AIS患者治疗过程中可通过调节血清miR-124、miR-145表达,发挥保护神经功能、抑制CAS斑块病变进展的作用。

关键词(KeyWords)： microRNA-124;microRNA-145;急性缺血性脑卒中;神经缺损程度;颈动脉粥样硬化;ROC

Abstract:

Keywords:

基金项目(Foundation): 河南省医学科技攻关计划项目(编号:201702132)

作者(Authors): 刘丽娇;杨秀丽;徐祥辉;秦毅;

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