刘月梅;梅道启;汤昱;李敏;

• 1:郑州大学附属儿童医院河南省儿童医院郑州儿童医院东区呼吸科

摘要(Abstract)：

目的探讨急性期病毒性脑炎(VE)患儿临床特点,并分析影响继发癫痫(SEP)的相关因素。方法收集2014-06—2017-06就诊于郑州大学附属儿童医院的76例急性期VE患儿的临床资料,对患儿临床特点进行统计分析,采用Logistic回归模型分析影响急性期VE后SEP的危险因素。结果 76例患儿中21例出现SEP,发生率为27.6%。单因素分析显示,VE后SEP组急性发作时出现癫痫持续状态、发作次数>10次的比例均明显高于非SEP组(P<0.05),急性期后继续服用抗癫痫药物(AEDs)比例明显低于非SEP组(P<0.05)。多因素Logistic回归分析显示,急性期出现癫痫持续状态(OR=1.570)、发作次数>10次(OR=1.988)是VE后发生SEP的危险因素(P<0.05),急性期后使用AEDs(OR=0.725)是VE后发生SEP的保护因素(P<0.05)。结论 VE患儿SEP发生率较高,癫痫持续状态、发作次数>10次是SEP发生的独立危险因素,建议急性期继续予以AEDs以预防SEP发生。

关键词(KeyWords)： 病毒性脑炎;癫痫;儿童;危险因素

Abstract:

Keywords:

基金项目(Foundation): 河南省医学科技攻关计划(联合共建项目)(编号:2018020633)

作者(Authors): 刘月梅;梅道启;汤昱;李敏;

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