袁咏梅;赵鑫;刘畅;杨宁;徐国卫;

• 1:郑州大学附属郑州中心医院急诊科
• 2:郑州大学附属郑州中心医院神经内科

摘要(Abstract)：

目的研究高血压脑出血(HIH)应激性高血糖患者miR-223、血清高迁移率族蛋白B1(HMGB1)水平对预后的判断价值。方法选取郑州大学附属郑州中心医院2017-03—2019-03收治的125例HIH患者,根据血糖水平分为正常血糖组和高血糖组,收集患者一般资料,比较空腹血脂、血糖水平、神经功能(NIHSS)评分;实时荧光定量PCR(qRT-PCR)法测定血清miR-223水平;酶联免疫吸附法(ELISA)测定血清HMGB1水平;受试者工作特征曲线(ROC)评估miR-223、HMGB1水平对患者预后的判断价值;Logistic回归分析影响预后的因素。结果与HIH正常血糖组相比,HIH高血糖组血糖水平、LDL-C水平、NIHSS评分、miR-223水平、HMGB1水平显著升高(P<0.05);与预后良好组相比,预后不良组患者血清miR-223、HMGB1水平显著升高(P<0.05);根据ROC曲线图可得知,miR-223、HMGB1判断HIH应激性高血糖患者不良预后曲线下面积分别为0.84(95%CI:0.721～0.921)、0.81(95%CI:0.687～0.899),截断值分别为1.67、4.77ng/mL;Logistic回归分析表明LDL-C水平、NIHSS评分、miR-223水平、HMGB1水平是影响HIH应激性高血糖患者不良预后的独立危险因素。结论miR-223、HMGB1在HIH应激性高血糖患者血清中水平升高,具有一定的预后判断价值,是影响此类患者不良预后的独立危险因素。

关键词(KeyWords)： 高血压脑出血;miR-223;血清高迁移率族蛋白B1;预后

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 袁咏梅;赵鑫;刘畅;杨宁;徐国卫;

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