冯微;张炜;李建玲;许风雷;罗瑞;高文;梁文宝;

• 1:克拉玛依市中心医院

摘要(Abstract)：

目的探讨25-羟维生素D3、Hcy、LDL与无症状性脑梗死患者颈动脉斑块的相关性。方法收集2014-01—2020-02克拉玛依市中心医院明确诊断为无症状脑梗死患者115例(SBI组),选取同期年龄、性别相匹配的123例健康者作对照(非SBI组)。入组人群均完善25-羟维生素D3、Hcy、TC、TG、HDL、LDL、头颅MRI、颈部血管超声。根据劲动脉超声将SBI组分为无斑块组、稳定斑块组和易损斑块组。采用单因素方差分析SBI组颈部血管无斑块组、稳定斑块组、易损斑块组的血清25-羟维生素D3、Hcy、TC、TG、HDL、LDL的相关性。采用Spearman相关性分析SBI组25-羟维生素D3与TC、TG、HDL、LDL、Hcy相关性。结果 2组在常见脑血管病危险因素中高血压、糖尿病、TG、HDL、LDL、25-羟维生素D3、Hcy、动脉硬化、饮酒、吸烟差异均有统计学意义(P<0.05)。SBI组25-羟维生素D3水平与Hcy、TC、TG、LDL水平呈负相关,与HDL水平呈正相关。SBI组LDL在易损斑块组>稳定斑块组>无斑块组,差异有统计学意义(P=0.015)。无症状脑梗死患者25-羟维生素D3水平在劲动脉无斑块组>稳定斑块组>易损斑块组,差异有统计学意义(P=0.021)。无症状脑梗死患者Hcy水平在劲动脉无斑块组<稳定斑块组<易损斑块组,差异有统计学意义(P=0.002)。25-羟维生素D3水平与LDL、Hcy水平呈负相关(r=-4.356,P=0.015;r=-0.276,P=0.003)。结论除常见无症状脑梗死的危险因素外,颈动脉粥样硬化斑块(稳定斑块及易损斑块)、25-羟维生素D3、Hcy、LDL也是无症状脑梗死的高危因素,且易损斑块与25-羟维生素D3、Hcy关系密切,在脑梗死的发生过程中三者扮演了重要的角色。25羟维生素D3水平、Hcy、LDL可作为无症状脑梗死患者临床初筛易损斑块的血清生物学标志物。

关键词(KeyWords)： 无症状性脑梗死;25-羟维生素D3;同型半胱氨酸;低密度脂蛋白;稳定斑块;易损斑块

Abstract:

Keywords:

基金项目(Foundation): 2019年克拉玛依市市级项目(编号:2019RC001A-17)

作者(Authors): 冯微;张炜;李建玲;许风雷;罗瑞;高文;梁文宝;

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