血管内取栓治疗急性后循环缺血性脑卒中临床分析Clinical analysis of intravascular thrombectomy for acute posterior circulation ischemic stroke
罗根培;李润雄;吴志强;胡伟东;石铸;吕科峰;郑伟城;倪卓新;詹云浩;赵江浩;
摘要(Abstract):
目的探讨血管内取栓治疗急性后循环缺血性脑卒中的安全性及有效性。方法回顾性收集东莞人民医院卒中中心2017-06—2019-12收治的18例急性椎基底动脉闭塞患者的基线资料及临床资料,术后90 d对患者进行随访。采用改良Rankin量表(mRS)评估患者的临床预后,并根据mRS评分将患者分为预后良好组(mRS 0~2分)及预后不良组(mRS 3~6分),进行单因素分析影响急性椎基底动脉闭塞取栓患者临床预后的相关因素。结果 18例患者取得成功再通15例(83.3%),获得良好预后10例(55.5%)。取得良好预后组患者其发病至股动脉穿刺时间更短(t=-2.192,P=0.044),术前NIHSS评分(Z=-2.408,P=0.016)及术后24 h NIHSS评分(Z=-3.560,P=0.000)更低,ASTIN/SIR评分(Z=-2.253,P=0.024)及BATMAN评分(Z=-3.319,P=0.001)更高。结论血管内取栓治疗急性后循环缺血性脑卒中安全有效,发病至股动脉穿刺时间、术前NIHSS评分及侧支循环评分(ASTIN/SIR评分及BATMAN评分)与良好功能预后相关。
关键词(KeyWords): 椎基底动脉闭塞;急性缺血性脑卒中;血管内治疗;支架;机械取栓
基金项目(Foundation): 广东省基础与应用基础研究基金(编号:2019A1515110031)
作者(Authors): 罗根培;李润雄;吴志强;胡伟东;石铸;吕科峰;郑伟城;倪卓新;詹云浩;赵江浩;
参考文献(References):
- [1] JANSSEN H,BRüCKMANN H,KILLER M,et al.Acute basilar thrombo-sis:recanalization following intravenous thrombolysis is dependent on thrombus length[J].PLoS One,2018,13(2):e0193051.
- [2] SAVER J L,GOYAL M,BONAFE A,et al.Stent-retriever thrombectomy after intravenous t-pa vs.T-pa alone in stroke[J].New Engl J Med,2015,;372(24):2285-2295.DOI:10.1056/NEJMoa1415061.
- [3] BARRAL M,LASSALLE L,DARGAZANLI C,et al.Predictors of favorable outcome after mechanical thrombectomy for anterior circulation acute ischemic stroke in octogenarians[J].J Neuroradiol,2018,45(4):211-216.DOI:10.1016/j.neurad.2018.01.055.
- [4] OTA T,NISHIYAMA Y,KOIZUMI S,et al.Impact of onset-to-groin puncture time within three hours on functional outcomes in mechanical thrombectomy for acute large-vessel occlusion[J].Interv Neuroradiol,2018,24(2):162-167.DOI:10.1177/1591019917747247.
- [5] ZAIDAT O,YOO A,KHATRI P,et al.Cerebral angiographic revascularization grading (carg) collaborators;stir revascularization working group;stir thrombolysis in cerebral infarction (tici) task force.Recommendations on angiographic revascularization grading standards for acute ischemic stroke:A consensus statement[J].Stroke,2013,44(9):2650-2663.DOI:10.1161/STROKEAHA.113.001972.
- [6] ALEMSEGED F,SHAH D G,DIOMEDI M,et al.The basilar artery on computed tomography angiography prognostic score for basilar artery occlusion[J].Stroke,2017,48(3)):631-637.DOI:10.1161/STROKEAHA.116.015492.
- [7] BOURCIER R,GOYAL M,LIEBESKIND D S,et al.Association of time from stroke onset to groin puncture with quality of reperfusion after mechanical thrombectomy:a meta-analysis of individual patient data from 7 randomized clinical trials[J].JAMA Neurol,2019,76(4):405-411.DOI:10.1001/jamaneurol.2018.4510.
- [8] 贺国华,王振.5例青年脑梗死患者病因及机械取栓治疗临床分析[J].中国实用神经疾病杂志,2018,21(16):1842-1846.
- [9] 龙建武,陈健,张鸿祺.急性基底动脉闭塞研究进展[J].中国实用神经疾病杂志,2017,20(19):1-4.
- [10] KAWABORI M,OSANAI T,GOTO S,et al.Direct common carotid artery puncture for acute thrombectomy against ischemic stroke[J].J Neurosurg Sci,2018,62(5):612-614.DOI:10.23736/S0390-5616.
- [11] GORY B,MAZIGHI M,BLANC R,et al.Mechanical thrombectomy in basilar artery occlusion:influence of reperfusion on clinical out-come and impact of the first-line strategy (ADAPT vs stent re-triever[J].J Neurosurg,2018,129(6):1482-1491.
- [12] POWERS W J,RABINSTEIN A A,ACKERSON T,et al.2018 guidelines for the early management of patients with acute ischemic stroke:A guideline for healthcare professionals from the american heart association/american stroke association[J].Stroke,2018,49(3):e46-e110.DOI:10.1161/STR.0000000000000158.
- [13] WRITING GROUP FOR THE BASILAR GROUP,ZI W,QIU Z,et al.Endovascular treatment for acute basilar artery occlusion:A nationwide prospective registry[J].JAMA Neurol,2020 Feb 20.DOI:10.1001/jamaneurol.2020.0156.
- [14] LIU X,DAI Q,YE R,et al.Endovascular treatment versus standard medical treatment for vertebrobasilar artery occlusion (best):An open-label,randomised controlled trial[J].Lancet Neurol,2020,19(2):115-122.DOI:10.1016/S1474-4422(19)30395-3.
- [15] GORY B,ELDESOUKY I,SIVAN-HOFFMANN R,et al.Outcomes of stent retriever thrombectomy in basilar artery occlusion:An observational study and systematic review[J].J Neurol Neurosurg Psychiatry,2016,87(5):520-5.DOI:10.1136/jnnp-2014-310250.
- [16] BOUSLAMA M,HAUSSEN DC,AGHAEBRAHIM A,et al.Predictors of good outcome after endovascular therapy for vertebrobasilar occlusion stroke[J].Stroke,2017,48(12):3252-3257.DOI:10.1161/STROKEAHA.117.018270.
- [17] KANG D H,JUNG C,YOON W,et al.Endovascular thrombectomy for acute basilar artery occlusion:A multicenter retrospective observational study[J].J Am Heart Assoc,2018,7(14).pii:e009419.DOI:10.1161/JAHA.118.009419.
- [18] SNELLING B M,SUR S,SHAH S S,et al.Unfavorable vascular anatomy is associated with increased revascularization time and worse outcome in anterior circulation thrombectomy[J].World Neurosurg,2018,120:e976-e983.DOI:10.1016/j.wneu.2018.08.207.
- [19] ROCHE A D,MURPHY B,ADAMS N,et al.Direct common carotid artery puncture for endovascular treatment of acute large vessel ischemic stroke in a patient with aortic coarctation[J].J Stroke Cerebrovasc Dis,2017,26(11):e211-e213.DOI:10.1016/j.jstrokecerebrovasdis.2017.07.017.