氯吡格雷预防非瓣膜病性心房颤动血栓栓塞的疗效观察
张普;梁雪;张佩生;
摘要(Abstract)：
目的观察氯吡格雷对非瓣膜病性心房颤动患者血栓栓塞并发症的预防效果和安全性。方法选取非瓣膜病性心房颤动患者96例随机分为2组,对照组常规以肠溶阿司匹林抗血小板治疗,150mg,1次/d;治疗组于肠溶阿司匹林100mg,在1次/d基础上加用氯吡格雷首剂负荷量300mg,以后50mg,1次/d,2组随访时间均为1.5年,观察2组1.5年内血栓栓塞并发症及出血等不良反应发生率,进行比较。结果治疗组用药后1.5年内血栓栓塞发生率为10%,对照组血栓栓塞发生率为36.96%,2组比较差异有统计学意义(P<0.01),出血等不良反应无明显差异。结论氯吡格雷能降低非瓣膜病房颤血栓栓塞发生率,安全有效,值得临床推广应用。
关键词(KeyWords)： 氯吡格雷;非瓣膜病性心房颤动;血栓栓塞;疗效
基金项目(Foundation):
作者(Authors): 张普;梁雪;张佩生;
参考文献(References)：
- (1)Petersen P.Placebo-controlled,randomized trial of warfarin andaspirin for prevention of thromboembolic complications in chronicatrial fibrillation.The Copenhagen AFASAK Study(J).Lancet,1989,1:175~179
- (2)Stroke prevention in atrial fibrillation investigators.Stroke preven-tion in atrial fibrillation study final results(J).Circulation,1991,84:527~539
- (3)European Atrial Fibrillation Trial Study Group.Optimal oral anti-coagulant therapy in patients with nonrheumatic atrial fibrillationand recent cerebral ischemia(J).N Engl J Med,1995,333:5~10
- (4)Lorenzoni R,Lazzerini G,Cocci F,et a1.Short-term prevention ofthromboembolic complications in patients with atrial fibrillationwith aspirin plus clopidogrel:The Clopidogrel-Aspirin Atrial Fi-brillation(CLAAF)pilot study(J).Am Heart J,2004,148(1):e6