姚川;张晓;董艳鹏;

• 1:南阳市第一人民医院

摘要(Abstract)：

目的探讨脑脊液脑型肌酸激酶同工酶(CK-BB)和腺苷脱氨酶(ADA)对化脓性脑膜炎(PM)与病毒性脑膜炎(VM)的诊断价值。方法收集2018-04—2020-04南阳市第一人民医院颅内感染患儿96例,其中VM 58例(VM组)和PM 38例(PM组),另选取同期住院的疑似偏头痛患儿24例(对照组)。患儿入院后24 h内均采集脑脊液检测CK-BB、ADA水平;采用受试者工作特征曲线(ROC)评价脑脊液CK-BB、ADA对VM、PM的诊断价值。结果对照组、VM组和PM组的CK-BB[(4.32±0.76)U/L vs (17.85±3.27)U/L vs (12.63±4.50)U/L]、ADA[(0.45±0.25)U/L vs (0.49±0.28)U/L vs (2.71±1.56)U/L]比较,差异均有统计学意义(P<0.05);两两比较显示,VM组CK-BB水平明显高于PM组和对照组,PM组ADA水平高于对照组,差异均有统计学意义(P<0.05);PM组ADA水平高于VM组、对照组(P<0.05),VM组和对照组ADA水平比较差异无统计学意义(P>0.05)。ROC曲线分析显示,CK-BB、ADA诊断PM的最佳截值分别为9.17 U/L、1.45 U/L;CK-BB、ADA诊断PM的AUC[0.741(95%CI:0.656～0.815) vs 0.818(95%CI:0.740～0.881)]比较,CK-BB明显小于ADA,差异有统计学意义(P<0.05);CK-BB诊断VM的最佳截值为12.06 U/L,AUC为0.834(95%CI:0.734～0.908)。结论颅内感染早期CK-BB≥12.06 U/L时对VM具有较好的诊断价值;ADA≥1.45 U/L时对PM具有较好的诊断价值。

关键词(KeyWords)： 颅内感染;病毒性脑膜炎;化脓性脑膜炎;脑型肌酸激酶同工酶;腺苷脱氨酶

Abstract:

Keywords:

基金项目(Foundation): 2018年度河南省医学科技攻关计划项目(编号:2018020924)

作者(Authors): 姚川;张晓;董艳鹏;

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