张德绸;葛建华;叶丽莎;冯启峰;

• 1:西南医科大学附属中医医院
• 2:西南医科大学附属医院

摘要(Abstract)：

目的探讨缺血性脑小血管病(ICSVD)致血管性认知功能障碍(VCI)的相关危险因素,为临床诊治提供参考。方法选取ICSVD及ICSVD合并VCI患者80例,其中ICSVD组32例,ICSVD合并VCI组48例,对照组30例(符合纳入标准的门诊体检人员)。采集所有对象的既往史、个人史、家族史,另外采集收缩压(SBP)及舒张压(DBP)、头颅MRI、颈动脉内膜-中膜厚度(IMT)、空腹血糖(FBG)、总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL)、同型半胱氨酸(Hcy)等资料。结果 3组受教育年限、不良习惯及合并疾病比较差异有统计学意义(P<0.05),但ICSVD组与ICSVD合并VCI组两两比较差异无统计学意义(P>0.05);3组彩超IMT、血压及血检数据比较差异有统计学意义(P<0.05),ICSVD组与ICSVD合并VCI组两两比较差异无统计学意义(P>0.05),但ICSVD组与ICSVD合并VCI组IMT和Hcy比较差异有统计学意义(P<0.05)。结论受教育年限短、吸烟、饮酒、高IMT、高血压、高血糖、高血脂、高Hcy是临床引起ICSVD及VCI重要危险因素;IMT及血清Hcy数值越高,颈动脉管径越细或狭窄,动脉粥样硬化越严重,可能是ICSVD引起VCI重要危险因素。

关键词(KeyWords)： 缺血性脑小血管病;血管性认知功能障碍;血管性痴呆;危险因素;血脂

Abstract:

Keywords:

基金项目(Foundation): 四川省教育厅课题(编号:16ZB0203)

作者(Authors): 张德绸;葛建华;叶丽莎;冯启峰;

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