于冰冰;王志涛;白倩;付红光;袁峰;杨现会;董铁立;

• 1:郑州大学第二附属医院麻醉科

摘要(Abstract)：

目的研究老年患者行食管癌根治术过程中应用右美托咪定对其早期认知功能和血清炎症因子水平的影响。方法选取2018-02—2019-02在郑州大学第二附属医院接受食管癌根治术的80例老年患者进行研究,随机分为试验组和对照组各40例。在全麻双腔支气管插管后,试验组静脉泵注右美托咪定,对照组静脉泵入等量生理盐水。采用简易智力状态检查法(MMSE)对2组老年患者在麻醉开始前(T1)、手术结束后第1天(T3)、手术结束后第3天(T4)的认知功能进行评价,同时记录T1、手术结束时(T2)、T3、T4时的炎症因子[肿瘤坏死因子(TNF-α)、血清白细胞介素-1β(IL-1β)]以及血清神经生物学标志物(S100β)和神经特异性烯醇化酶(NSE)。结果与T1时间点相比,2组在T3、T4时间点的MMSE评分降低(P<0.05)。与对照组相比,试验组在T3、T4时间点的MMSE评分增高(P<0.05);与T1时间点相比,2组在T2、T3、T4时间点的TNF-α、IL-1β水平均增高(P<0.05),与对照组相比,试验组在T2、T3、T4时间点的TNF-α、IL-1β水平均降低(P<0.05);与T1时间点相比,2组在T2、T3时间点的S100β和NSE水平均增高(P<0.05),与对照组相比,试验组在T2、T3时间点的S100β和NSE水平均降低(P<0.05)。结论全麻插管后静脉泵入右美托咪定,不仅可有效减轻老年食管癌患者术后的认知功能下降水平,还可降低炎症因子和血清S100β、NSE水平。

关键词(KeyWords)： 老年人;食管癌根治术;右美托咪定;认知功能;炎症因子;神经损伤标志物

Abstract:

Keywords:

基金项目(Foundation): 河南省科技攻关项目(编号:2018020156)

作者(Authors): 于冰冰;王志涛;白倩;付红光;袁峰;杨现会;董铁立;

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