丁苯酞对血管性痴呆大鼠认知功能及海马区Aβ表达的影响Experiment study on cognitiue function and expression of Aβ in hippocampus of vascular dementia rats with butyphthalide
窦雯;杜业亮;刘英;李增芬;
摘要(Abstract)：
目的研究丁苯酞对血管性痴呆大鼠认知功能及海马区Aβ表达的影响,探讨丁苯酞的脑保护作用。方法采用双侧颈总动脉永久结扎法制备血管性痴呆动物模型,以Morris水迷宫检测大鼠认知功能,以免疫组化法测定大鼠海马区Aβ的表达。结果模型组与假手术组相比,认知功能明显下降(P<0.05),Aβ表达明显增加(P<0.05);治疗组与模型组相比认知功能明显改善(P<0.05),Aβ表达明显减少(P<0.05);其中高剂量丁苯酞组较低剂量丁苯酞组认知功能改善明显、Aβ表达减少(P<0.05)。结论血管性痴呆大鼠海马区Aβ表达增加,给予丁苯酞治疗后,可通过减少海马区Aβ的表达,抑制神经细胞凋亡,保护神经细胞,促进脑功能恢复,从而改善血管性痴呆的认知功能障碍。
关键词(KeyWords)： 丁苯酞;血管性痴呆;海马;Aβ
基金项目(Foundation):
作者(Authors): 窦雯;杜业亮;刘英;李增芬;
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