李雨晴;张佩兰;

• 1:天津市环湖医院

摘要(Abstract)：

目的探讨急性缺血性脑卒中患者阿替普酶(rt-PA)静脉溶栓治疗后出现口舌部血管性水肿(orolingual angioedema,OA)的相关因素,以提高rt-PA相关性口舌部血管性水肿的预测能力。方法回顾性分析2019-06—2020-08于天津市环湖医院神经内科四病区接受rt-PA静脉溶栓治疗的1 218例急性缺血性脑卒中患者的资料,分析静脉溶栓治疗后发生口舌部血管性水肿的相关因素。结果共纳入1 218例接受rt-PA静脉溶栓的急性缺血性脑卒中患者,其中13例(男5例,女8例)在应用rt-PA后出现OA,发病率为1.07%。13例患者中9例为静脉溶栓过程中发生OA,4例静脉溶栓后发生OA,其中10例表现为口唇水肿,8例表现广泛舌部肿胀,3例表现半侧舌部肿胀,2例合并呼吸窘迫。6例曾口服血管紧张素转换酶抑制剂(ACEI)类降压药。结论口舌部血管性水肿是rt-PA静脉溶栓治疗后少见的并发症,口服ACEI类降压药、既往过敏史可增加口舌部血管性水肿的风险。

关键词(KeyWords)： 阿替普酶;急性缺血性脑卒中;口舌部血管性水肿;静脉溶栓;血管紧张素转化酶抑制剂

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 李雨晴;张佩兰;

参考文献(References)：

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