李晴;于小琪;王双艳;陈劲龙;

• 1:华南理工大学附属第二医院广州市第一人民医院老年病科

摘要(Abstract)：

目的观察和评价鼠神经生长因子(mNGF)联合瑞舒伐他汀治疗糖尿病周围神经病变(DPN)的疗效。方法 67例老年DPN患者随机分为3组:A组(n=23)给予甲钴胺治疗,B组(n=22)给予甲钴胺+鼠神经生长因子治疗,C组(n=22)给予甲钴胺+鼠神经生长因子+瑞舒伐他汀治疗,共4周;观察各组患者治疗前后的多伦多神经症状评分(TCSS)、神经传导速度(NCV)以及肝功能和血脂变化。结果 3组治疗后均取得TCSS下降和NCV增加的显著改善(P<0.05),其中C组较A、B组改善程度更优,差异具有统计学意义(P<0.05)。结论联合使用mNGF和瑞舒伐他汀治疗老年DPN可能获得显著疗效。

关键词(KeyWords)： 鼠神经生长因子;瑞舒伐他汀;糖尿病周围神经病变

Abstract:

Keywords:

基金项目(Foundation): 广州市医药卫生科技项目(编号：20151A1003)

作者(Authors): 李晴;于小琪;王双艳;陈劲龙;

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