张雪玲;陈晓轶;郭建梅;

• 1:河南科技大学第一附属医院
• 2:郑州大学附属儿童医院河南省儿童医院郑州儿童医院

摘要(Abstract)：

目的探讨甲基强的松龙(MP)冲击疗法治疗重症病毒性脑炎(VE)患儿疗效及对血清C反应蛋白(CRP)、降钙素原(PCT)、肿瘤坏死因子α(TNF-α)水平的影响。方法选取2016-02—2019-11就诊的重症VE患儿68例,随机分为试验组与对照组各34例。2组均进行一般治疗,对照组采用纳洛酮及神经节苷脂治疗,试验组在该基础上使用MP冲击疗法。比较2组治疗效果、临床特征消失时间、血清指标水平变化、不良反应。结果治疗后试验组总有效率为91.51%,高于对照组的73.58%(P<0.05);试验组各类临床症状消失时间早于对照组(P<0.05);试验组CRP、PCT、TNF-α、中枢神经特异性蛋白(S-100β)、人可溶性血管细胞黏附因子(sVCAM-1)、神经烯醇化酶(NSE)含量均低于对照组(P<0.05)。2组不良反应发生率比较无显著差异(P>0.05)。结论 MP冲击疗法治疗重症VE患儿具有更好的临床效果,并显著降低血清炎症因子水平。

关键词(KeyWords)： 重症病毒性脑炎;甲基强的松龙;C反应蛋白;降钙素原;肿瘤坏死因子α

Abstract:

Keywords:

基金项目(Foundation): 2019年度河南省医学科技攻关计划联合共建项目(编号:LHGJ20190944)

作者(Authors): 张雪玲;陈晓轶;郭建梅;

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