周鑫;陈晓莉;刘惠惠;杨谦;郭荷娜;

• 1:西安医学院
• 2:陕西省人民医院神经内二科

摘要(Abstract)：

目前研究已经发现长链非编码RNA(Long non-coding RNA,LncRNA)在肿瘤、神经系统疾病、心血管疾病、精神障碍疾病等方面起重要作用,在缺血性脑卒中中,局灶性缺血使LncRNA表达谱发生明显改变,同时,各种因素所致的LncRNA的表达水平变化也可以通过影响脂代谢、平滑肌增殖、血管炎性作用、血管内皮细胞损伤等机制导致缺血性脑卒中的发生。对LncRNA在缺血性脑卒中疾病作用机制靶点的了解有助于缺血性脑卒中的诊断和治疗,最终为缺血性脑卒中的诊断和治疗提供新的策略。

关键词(KeyWords)： 长链非编码RNA;缺血性脑卒中;局灶性脑缺血;作用靶点;脂代谢;平滑肌细胞;血管炎性作用;内皮细胞损伤

Abstract:

Keywords:

基金项目(Foundation): 陕西省重点研发计划项目,编号:2017SF-096

作者(Authors): 周鑫;陈晓莉;刘惠惠;杨谦;郭荷娜;

参考文献(References)：

• [1]CARNINCI P,KASUKAWA T,KATAYAMA S,et al.The transcriptional landscape of the mammalian genome[J].Science,2005,309(5 740):1 559-1 563.
• [2]CAO J.The functional role of long non-coding RNAs and epigenetics[J].Biol Proced Online,2014,16:11.
• [3]ST LG,WAHLESTEDT C,KAPRANOV P.The Landscape of long noncoding RNA classification[J].Trends Genet,2015,31(5):239-251.
• [4]LEUNG A,NATARAJAN R.Noncoding RNAs in vascular disease[J].Curr Opin Cardiol,2014,29(3):199-206.
• [5]LI J,XUAN Z,LIU C.Long non-coding RNAs and comp-lex human diseases[J].Int J Mol Sci,2013,14(9):18 790-18 808.
• [6]HOMMEL M,AUID-OHO,DETANTE O,et al.How to Measure Recovery?Revisiting Concepts and Methods for Stroke Studies[J].Transl Stroke Res,2016,7(5):388-394.
• [7]DHARAP A,NAKKA V P,VEMUGANTI R.Effect of focal ischemia on long noncoding RNAs[J].Stroke,2012,43(10):2 800-2 802.
• [8]ADAMS H P J R,BENDIXEN B H,KAPPELLE L J,et al.Classification of subtype of acute ischemic stroke.Definitions for use in a multicenter clinical trial.TOAST.Trial of Org 10172in Acute Stroke Treatment[J].Stroke,1993,24(1):35-41.
• [9]KOO J.The Latest Information on Intracranial Atherosclerosis:Diagnosis and Treatment[J].Interv Neurol,2015,4(1-2):48-50.
• [10]YUAN Y,LI P,YE J.Lipid homeostasis and the formation of macrophage-derived foam cells in atherosclerosis[J].Protein Cell,2012,3(3):173-181.
• [11]HO-TIN-NOE B,MICHEL J B.Initiation of angiogenesis in atherosclerosis:smooth muscle cells as mediators of the angiogenic response to atheroma formation[J].Trends Cardiovasc Med,2011,21(7):183-187.
• [12]HUANG P H,CHEN J W,LIN S J.Effects of Cardiovascular Risk Factors on Endothelial Progenitor Cell[J].Acta Cardiol Sin,2014,30(5):375-381.
• [13]LI P,RUAN X,YANG L,et al.A liver-enriched long non-coding RNA,lncLSTR,regulates systemic lipid metabolism in mice[J].Cell Metab,2015,21(3):455-467.
• [14]HALLEY P,KADAKKUZHA B M,FAGHIHI M A,et al.Regula-tion of the apolipoprotein gene cluster by a long noncoding RNA[J].Cell Rep,2014,6(1):222-230.
• [15]LEUNG A,TRAC C,JIN W,et al.Novel long noncoding RNAs are regulated by angiotensin II in vascular smooth muscle cells[J].Circ Res,2013,113(3):266-278.
• [16]BALLANTYNE M D,PINEL K,DAKIN R,et al.Smooth Muscle Enriched Long Noncoding RNA(SMILR)Regulates Cell Proliferation[J].Circulation,2016,133(21):2 050-2 065.
• [17]CARPENTER S,AIELLO D,ATIANAND M K,et al.A long noncoding RNA mediates both activation and repression of immune response genes[J].Science,2013,341(6 147):789-792.
• [18]FISH J E,MATOUK C C,YEBOAH E,et al.Hypoxia-induci-ble expression of a natural cis-antisense transcript inhibits endothelial nitric-oxide synthase[J].J Biol Chem,2007,282(21):1 5 652-15 666.
• [19]CHEN C,CHENG G,YANG X,et al.Tanshinol suppresses endothelial cells apoptosis in mice with atherosclerosis via lncRNA TUG1 up-regulating the expression of miR-26a[J].Am J Transl Res,2016,8(7):2 981-2 991.
• [20]SHAN K,JIANG Q,WANG X Q,et al.Role of long non-coding RNA-RNCR3in atherosclerosis-related vascular dysfunction[J].Cell Death Dis,2016,7(6):e2 248.
• [21]ZHANG W,CHEN Y,LIU P,et al.Variants on chromo-some 9p21.3correlated with ANRIL expression contribute to stroke risk and recurrence in a large prospective stroke population[J].Stroke,2012,43(1):14-21.
• [22]BAI Y,NIE S,JIANG G,et al.Regulation of CARD8expression by ANRIL and association of CARD8single nucleotide polymorphism rs2043211(p.C10X)with ischemic stroke[J].Stroke,2014,45(2):383-388.
• [23]DIRNAGL U,IADECOLA C,MOSKOWITZ M A.Pathobiology of ischaemic stroke:an integrated view[J].Trends Neurosci,1999,22(9):391-397.
• [24]WOODRUFF T M,THUNDYIL J,TANG S C,et al.Pathophysiology,treatment,and animal and cellular models of human ischemic stroke[J].Mol Neurodegener,2011,6(1):11.
• [25]DHARAP A,POKRZYWA C,VEMUGANTI R.Increased bind-ing of stroke-induced long non-coding RNAs to the transcriptional corepressors Sin3A and coREST[J].ASN Neuro,2013,5(4):283-289.
• [26]MEHTA S L,KIM T,VEMUGANTI R.Long Noncoding RNA FosDT Promotes Ischemic Brain Injury by Interacting with REST-Associated ChromatinModifying Proteins[J].J Neurosci,2015,35(50):16443-16 449.
• [27]XU Q,DENG F,XING Z,et al.Long non-coding RNA C2dat1regulates CaMKIIdelta expression to promote neuronal survival through the NF-kappaB signaling pathway following cerebral ischemia[J].Cell Death Dis,2016,7:e2 173.
• [28]ZHANG A,ZHOU N,HUANG J,et al.The human long non-coding RNA-RoR is a p53repressor in response to DNA damage[J].Cell Res,2013,23(3):340-350.
• [29]PUYAL J,GINET V,CLARKE P G.Multiple interacting cell death mechanisms in the mediation of excitotoxicity and ischemic brain damage:a challenge for neuroprotection[J].Prog Neurobiol,2013,105:24-48.
• [30]YAN H,YUAN J,GAO L,et al.Long noncoding RNA MEG3 activation of p53 mediates ischemic neuronal death in stroke[J].Neuroscience,2016,337:191-199.