张营丽;周艳华;李卓;王瑾;唐伟;王威;

• 1:盘锦市中心医院
• 2:大连大学附属新华医院
• 3:大连大学附属中山医院

摘要(Abstract)：

目的探讨正念冥想疗法对阿尔茨海默病患者神经损伤及焦虑、抑郁的干预效果。方法选择2018-01—2019-07在盘锦市中心医院接受治疗的70例老年痴呆患者为研究对象,随机分为2组,实验组接受正念冥想疗法,对照组接受常规治疗。测定干预前后2组血清神经损伤指标水平,应用汉密尔顿焦虑量表(HAMA-14)、汉密尔顿抑郁量表(HAMD-17)评估治疗前后2组患者焦虑、抑郁情况。结果干预后实验组患者血清Aβ_(1-42)、Tau蛋白含量明显降低,血清PON1、SOD含量明显升高,差异均有统计学意义(P<0.05);实验组血清Aβ_(1-42)、Tau蛋白含量低于对照组,血清PON1、SOD含量高于对照组,差异均有统计学意义(P<0.05)。干预后实验组HAMD-17评分、HAMA-14评分明显低于对照组,差异均有统计学意义(P<0.05)。结论正念冥想能够减轻阿尔茨海默病患者的脑内神经损伤,改善焦虑、抑郁症状。

关键词(KeyWords)： 阿尔茨海默病;正念冥想;神经损伤;焦虑;抑郁

Abstract:

Keywords:

基金项目(Foundation): 大连市卫计委科研课题(编号:1911105);; 辽宁省教育厅高等学校科学研究项目(编号:2008033)

作者(Authors): 张营丽;周艳华;李卓;王瑾;唐伟;王威;

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