p38MAPK通路在脑缺血再灌注损伤中的研究进展Research progress of p38MAPK pathway in cerebral ischemia-reperfusion injury
翁雨天;黄茜;杨旭娟;刘国光;刘一丹;
摘要(Abstract):
p38MAPK通路是MAPK通路的重要组成部分,介导多种转录因子的表达,在细胞炎症、侵袭、凋亡中发挥着重要作用。脑缺血再灌注损伤是缺血的脑组织在恢复供血的情况下,损伤程度加重的病理现象。近些年研究发现p38MAPK通路与脑缺血再灌注损伤息息相关。本文就近年来对p38MAPK通路与脑缺血再灌注损伤的机制研究进展进行综述。
关键词(KeyWords): p38MAPK通路;脑缺血再灌注损伤;炎性因子;MMP-9;细胞凋亡
基金项目(Foundation): 国家重点研发计划(编号:2017YFC1702504)
作者(Authors): 翁雨天;黄茜;杨旭娟;刘国光;刘一丹;
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