李栋方;邓巧儿;何展文;唐丹霞;孙怡;罗向阳;

• 1:中山大学孙逸仙纪念医院

摘要(Abstract)：

目的回顾性分析儿童难治性细菌性脑膜炎患儿的临床数据,以期提高儿童细菌性脑膜炎的诊治经验。方法回顾性分析31例儿童难治性细菌性脑膜炎及病程>1个月的住院患儿的临床资料。结果在抗生素治疗的基础上,大部分病例联合应用免疫治疗,发病后1 a成功随访23例,预后不良率高(69.57%);患儿住院期间血淋巴细胞亚群以CD19⁺、NK、CD20出现异常率较高(>50%),50%以上的患儿停用抗生素时不符合国内常见停药标准,应用免疫治疗对患儿预后的影响差异无统计学意义(P>0.05)。结论儿童难治性细菌性脑膜炎常出现外周血淋巴细胞亚群比例异常,临床应重视加强免疫方面的检查及治疗。临床决定患儿是否停用抗生素应多因素综合考虑及个体化治疗,为患儿制定最佳停用抗生素时间点。免疫调节治疗的长期效果仍待观察。

关键词(KeyWords)： 难治性细菌性脑膜炎;血淋巴细胞亚群;抗生素治疗;免疫治疗;儿童

Abstract:

Keywords:

基金项目(Foundation): 2020年广东省自然科学基金(编号：2020A1515010312)

作者(Authors): 李栋方;邓巧儿;何展文;唐丹霞;孙怡;罗向阳;

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