吕国伟;姜羽;辛孟杰;张文进;张辉;朱旭强;

• 1:郑州大学附属郑州中心医院
• 2:郑州大学第一附属医院

摘要(Abstract)：

目的分析神经内镜微创术对高血压脑出血(HICH)患者血清神经元特异性烯醇化酶(NSE)、胱抑素C(Cys-C)的影响及其与预后的相关性。方法回顾性分析2016-01—2019-01郑州大学附属郑州中心医院就诊的高血压脑出血患者78例,均行神经内镜微创手术,根据格拉斯哥预后评分(GOS),术后4～5分患者49例为预后良好组,1～3分患者29例为预后不良组,分析术后NSE及Cys-C变化及预后危险因素。结果术后患者血清NSE、Cys-C水平均下降,且预后良好组均低于预后不良组(P<0.05)。以术后血清NSE、Cys-C预测患者预后不良时,两项指标联合的AUC最大为0.836,高于单一的NSE、Cys-C的0.788、0.737(P<0.05);单因素分析显示,年龄、出血量、出血破入脑室、入院时GCS评分、NSE、Cys-C与患者预后不良显著相关(P<0.05);多因素分析显示,年龄≥60岁、出血量≥50 mL、出血破入脑室、入院时GCS评分≤6分、NSE≥10.827μg/mL、Cys-C≥1.545 mg/L是患者预后不良的独立危险因素。结论神经内镜微创术后HICH患者NSE、Cys-C水平均降低,多因素分析表明年龄≥60岁、脑出血量≥50 mL、出血破入脑室、入院时GCS评分≤6分、术后NSE≥10.827μg/mL、Cys-C≥1.545 mg/L是患者预后不良的独立危险因素,临床应重视监测患者NSE、Cys-C水平,以改善患者预后。

关键词(KeyWords)： 高血压脑出血;神经内镜微创术;神经元特异性烯醇化酶;胱抑素C;预后

Abstract:

Keywords:

基金项目(Foundation): 河南省高等学校重点科研项目(编号:19A320041)

作者(Author): 吕国伟;姜羽;辛孟杰;张文进;张辉;朱旭强;

Email:

DOI:

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