康梅娟;温昌明;张保朝;孙军;刘义锋;汪宁;张东焕;楚黎君;

• 1:南阳市中心医院

摘要(Abstract)：

目的分析超时间窗后循环缺血性脑梗死应用TREVO支架取栓再通的有效性及其对丝氨酸蛋白酶抑制剂(Vaspin)、认知功能的影响。方法收集2016-01—2019-12南阳市中心医院超时间窗后循环缺血性脑梗死患者100例,根据随机数字表法分成观察组和对照组各50例。对照组采用人组织型纤溶酶原激活剂(rt-PA)进行静脉溶栓治疗,观察组采用TREVO支架取栓治疗。分析比较患者术前及术后72 h、90 d的NIHSS评分、MoCA评分、血清Vaspin水平,术后90 d mRS评分、并发症发生情况、复发率、病死率。结果 2组患者术后72 h、90 d相较术前NIHSS评分均降低,MoCA评分、血清Vaspin水平均升高,且观察组优于对照组。术后90 d观察组的并发症发生情况、复发率优于对照组,mRS评分≤2者占比观察组(58%)显著高于对照组(38%),2组患者术后90 d的病死率无明显差异(P>0.05)。结论 TREVO支架取栓再通对超时间窗后循环缺血性脑梗死患者疗效显著,能够明显提高术后患者血清Vaspin水平,有效促进患者神经功能恢复,提高认知功能,改善预后。

关键词(KeyWords)： 超时间窗;后循环缺血性脑梗死;组织型纤溶酶原激活剂;TREVO支架;血管再通

Abstract:

Keywords:

基金项目(Foundation): 河南省科技发展计划项目（编号：192102310349）

作者(Authors): 康梅娟;温昌明;张保朝;孙军;刘义锋;汪宁;张东焕;楚黎君;

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