张杨;蒋森;刘娜;钱小娟;杨新玲;

• 1:新疆医科大学第二附属医院

摘要(Abstract)：

目的探究早期帕金森病患者行走时的步态特征。方法收集2020-06—2021-09在新疆医科大学第二附属医院神经内科住院就诊的帕金森病(PD)患者51例(H-Y分级≤2.5),以及同时期前来体检或来自社会的健康人群为对照组。使用GaitWatch三维步态动作捕捉与训练系统进行步态数据的收集,对各项步态数据进行定量及相关性分析。结果帕金森病组步态周期较对照组降低[分别为(1.41±0.698)s、(1.43±0.586)s,P=0.004],帕金森病组步长偏差较对照组增大[分别为(7.69±11.415)cm、(3.15±3.121)cm,P=0.007],帕金森病组比对照组步幅降低[(62±40)cm、(88±17)cm,P<0.001],帕金森病组与对照组间步频、步速、支撑相、摆动相比较差异无统计学意义(P≥0.05)。帕金森病组与对照组比较,步幅与帕金森病呈正相关,步长偏差与帕金森病呈负相关。ROC曲线分析显示,对于步长偏差,区分帕金森病组与对照组的最佳截止值为3.5 cm(灵敏度为0.392,特异度为0.362,曲线下面积为0.343)。对于步幅,区分帕金森病组与对照组的最佳截止值为68 cm(灵敏度为0.608,特异度为0.936,曲线下面积为0.815)。结论对早期帕金森病患者量化的步态参数可以反映其步态特征,早期帕金森病患者步态周期、步幅降低,步长偏差增大。

关键词(KeyWords)： 帕金森病;步态特征;定量分析;步态周期;步幅;步长

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金（编号：81960243）;; 新疆维吾尔自治区科技援疆计划项目（编号：2019E0280）

作者(Authors): 张杨;蒋森;刘娜;钱小娟;杨新玲;

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