吴海燕;张平;

• 1:商丘市中心医院
• 2:新乡医学院第一附属医院

摘要(Abstract)：

目的探讨脑梗死患者血清高敏C反应蛋白(hs-CRP)、氧化低密度脂蛋白(ox-LDL)的表达及意义。方法选取2018-01—2019-12商丘市中心医院治疗的急性脑梗死患者220例(观察组),其中大动脉粥样硬化型(LAA)108例,小动脉闭塞型(SAO)82例,心源性栓塞型(CE)30例,同时选取健康体检者100例为对照组,检测血清hs-CRP、ox-LDL表达水平。结果观察组血清hs-CRP、ox-LDL水平明显高于对照组(P<0.05);观察组CE型患者血清hs-CRP水平明显高于LAA和SAO型患者(P<0.05);观察组LAA型患者血清ox-LDL水平、NIHSS评分明显高于SAO和CE型患者(P<0.05),血清hs-CRP、ox-LDL水平与NIHSS评分呈正相关(r=0.398、0.404,P<0.05),hs-CRP与ox-LDL呈正相关(r=0.480,P<0.05)。结论不同分型脑梗死患者血清hs-CRP、ox-LDL表达有所差异,与神经功能缺损程度有关。

关键词(KeyWords)： 脑梗死;高敏C反应蛋白;氧化低密度脂蛋白;神经功能缺损;血清

Abstract:

Keywords:

基金项目(Foundation): 河南科技计划攻关项目（编号：SB201901061）

作者(Authors): 吴海燕;张平;

参考文献(References)：

• [1]程弘禹，李丹，郑圆.急性脑梗死患者相关血液标志物水平及颈动脉内中膜厚度的研究[J].中国实用神经疾病杂志，2020,23(8):672-677.DOI:10.12083/SYSJ.2020.08.159.
• [2] CHEN Y,HUANG W,LI Z,et al. The effect of acupuncture on the expression of inflammatory factors TNF-α，IL-6,IL-1 and CRP in cerebral infarction:A protocol of systematic review and meta-analysis[J]. Medicine,2019,98(24):e15408. DOI:10.1097/MD. 0000000000015408.
• [3]陆小林，林志伟，陈丽芳，等.ApoE基因多态性与动脉粥样硬化性脑梗死的相关性研究[J].中国实用神经疾病杂志，2018,21(22):2463-2469. DOI:10.12083/SYSJ.2018.22.524.
• [4]李映雪，高雪雷.探讨经颅多普勒评价瑞舒伐他汀治疗动脉粥样硬化性脑梗死的作用[J].中国实用神经疾病杂志，2017,20(1):32-34.
• [5] BULENT B A,ABDULLAH T,BAHADIR O,et al. Comparative effects of high-dose atorvastatin versus rosuvastatin on lipid parameters,oxidized low-density lipoprotein,and proprotein convertase subtilisin kexin 9 in acute coronary syndrome[J]. Coronary Artery Dis,2019,30(4):285-290. DOI:10.1097/MCA.0000000000000715.
• [6] XIAOFENG D,FANZHEN K,MINGQIANG S,et al. Triiodothyronine levels were positively correlated with opening of collateral circulation in cerebral infarction patients with large artery atherosclerosis[J].Arch Med Sci,2020,16(1):51-57.DOI:10.5114/aoms.2020.91286.
• [7] MIN L,JING W,XINHONG W,et al. Clinical efficacy of aspirin combined with clopidogrel in treating cerebral infarction and its effect on serum hs-CRP,s ICAM-1 and TNF-α[J].Exp Ther Med,2020,19(2):939-944. DOI:10.3892/etm.2019.8275.
• [8] LILI T,RUIFENG M. Long Non-Coding RNA MALAT1 Promotes Acute Cerebral Infarction Through miRNAs-Mediated hs-CRP Regulation[J].J M N,2019,69(3):494-504. DOI:10.1007/s12031-019-01384-y.
• [9] LüTFüH,ELMIR K,SEMA D,et al.Anterior cerebral artery infarcts;two years follow-up study[J].Ideggyogy Sz,2018,71(9/10):331-336. DOI:10.18071/isz.71.0331.
• [10] MENACHEM G,MOJDEH K,MANGAIYARKKARASI S,et al. Right-left propensity of cardiogenic cerebral embolism in standard versus bovine aortic arch variant[J]. Clin Anat,2018,31(3):310-313. DOI:10.1002/ca.23045.
• [11] JIUMIN Y,CHONGBAO W,DONGQI W,et al. LncRBA GSA5,up-regulated by ox-LDL,aggravates inflammatory response and MMP expression in THP-1 macrophages by acting like a sponge for miR-221[J].Exp Cell Res,2018,369(2):348-355. DOI:10.1016/j.yexcr.2018.05.039.
• [12] ZHEN Y,BAOSHENG F,DAN H,et al. The relationship between oxidized low-density lipoprotein and related ratio and acute cerebral infarction[J]. Medicine,2018,97(39):e12642.DOI:10.1097/MD. 0000000000012642.
• [13] LIANG T,WANG S C,ZHANG D T,et al.Evaluation of lipoprotein-associated phospholipase A2,serum amyloid A,and fibrinogen as diagnostic biomarkers for patients with acute cerebral infarction[J].J Clin Lab Anal,2020,34(3):e23084. DOI:10.1002/jcla.23084.
• [14]李青华. H型高血压并发急性脑梗死同型半胱氨酸水平升高的危险因素分析[J].中国实用神经疾病杂志，2018,21(4):410-413. DOI:10.12083/SYSJ.2018.04.104.
• [15] WENYI L,YUANQING M,LIN Z,et al.MiR-211 protects cerebral ischemia/reperfusion injury by inhibiting cell apoptosis[J]. Bioengineered,2020,11(1):189-200. DOI:10.1080/21655979.2020.1729322.
• [16] BIXIAO C,TIANHAO Z,YAN M,et al.Simultaneous PET-MRI imaging of cerebral blood flow and glucose metabolism in the symptomatic unilateral internal carotid artery/middle cerebral artery steno-occlusive disease[J].Eur J Nucl Med Mol I,2020,47(7):1668-1677.DOI:10.1007/s00259-019-04551-w.
• [17] SUNG HO J,JUN L,YOU SUNG S.Motor recovery by the aberrant pyramidal pathway in a patient with cerebral infarct[J].Medicine,2020, 99(22):e20282. DOI:10.1097/MD.0000000000020282.
• [18] SEBASTIAN W,ANNE GR?NBORG V,FREDERIK H,et al.Lack of Association Between Gaseous Microembolisms Assessed by a Single Detection Device and Cerebral Complications in Cardiac Surgery Patients[J].J Cardiothor Vasc An,2020,34(6):1496-1503.DOI:10.1053/j.jvca.2019.12.020.
• [19] DONGJU P,JUBIN K,PHILOK K.Epigallocatechin gallate alleviates neuronal cell damage against focal cerebral ischemia in rats[J].J Vet Med Sci,2020,82(5):639-645. DOI:10.1292/jvms.19-0703.
• [20] XU R,YIN X,XU W,et al. Assessment of carotid plaque neovascularization by contrast-enhanced ultrasound and high sensitivity C-reactive protein test in patients with acute cerebral infarction:a comparative study[J]. Neurol Sci,2016,37(7):1107-1112. DOI:10.1007/s10072-016-2557-2.
• [21] WANG H. Predictive value of serum procalcitonin and hypersensitive C-reactive protein levels in patients with acute cerebral infarction complicated with infection[J]. Zhonghua Wei Zhong Bing Ji Jiu Yi Xue,2019,31(8):962-966. DOI:10.3760/cma.j.issn.2095-4352.2019.08.010.
• [22] HAN Y,WU S,HU Q,et al.Thrombomodulin and High-Sensitive C-Reactive Protein Levels in Blood Correlate with the Development of Cerebral Infarction Among Asians[J]. Mol Neurobiol,2016,53(4):2659-2667. DOI:10.1007/s12035-015-9279-y.
• [23] ZHAO L,ZHAI Z,HOU W. Analysis of Carotid color ultrasonography and high sensitive C-reactive protein in patients with atherosclerotic cerebral infarction[J]. Pak J Med Sci,2016,32(4):931-4. DOI:10.12669/pjms.324.9731.
• [24] WANG J H,ZHAO M,BAO Y C,et al.Effect of Scalp-acupuncture Treatment on Levels of Serum High-sensitivity C-reactive Protein,and Pro-inflammatory Cytokines in Patients with Acute Cerebral Infarction[J]. Zhen Ci Yan Jiu,2016,41(1):80-84.
• [25] YOSHINAGA R,DOI Y,AYUKAWA K,et al. High-sensitivity C reactive protein as a predictor of inhospital mortality in patients with cardiovascular disease at an emergency department:a retrospective cohort study[J]. BMJ Open,2017,7(10):e015112. DOI:10.1136/bmjopen-2016-015112.
• [26] CAI Z,HE W,ZHUANG F J,et al. The role of high high-sensitivity C-reactive protein levels at admission on poor prognosis after acute ischemic stroke[J]. Int J Neurosci,2019,129(5):423-429. DOI:10.1080/00207454.2018.1538139.
• [27] ZHOU P,LI YQ,LI W D,et al.Changes in serum high mobility group box-1 protein and high-sensitivity C-reactive protein in patients with acute cerebral infarction and their clinical significance[J]. Zhongguo Wei Zhong Bing Ji Jiu Yi Xue,2012,24(5):265-268.
• [28] ANAN F,SHIMOMURA T,KAKU T,et al.High-sensitivity C-reactive protein level is a significant risk factor for silent cerebral infarction in patients on hemodialysis[J]. Metabolism,2008,57(1):66-70. DOI:10.1016/j.metabol.2007.08.007.
• [29] HEIDER P,POPPERT H,WOLF O,et al.Fibrinogen and high-sensitive C-reactive protein as serologic predictors for perioperative cerebral microembolic lesions after carotid endarterectomy[J]. J Vasc Surg,2007,46(3):449-54. DOI:10.1016/j.jvs.2007.05.035.
• [30] GUO A S,LI AH,CHEN X,et al.Effect of acupoint catgut embedding on motor function and serum high sensitivity C-reactive protein and IL-6 levels in patients with acute cerebral infarction[J]. Zhen Ci Yan Jiu,2013,38(3):224-228;258.
• [31] KAWAMURA T,UMEMURA T,KANAI A,et al. Soluble adhesion molecules and C-reactive protein in the progression of silent cerebral infarction in patients with type 2 diabetes mellitus[J]. Metabolism,2006,55(4):461-466.DOI:10.1016/j.metabol.2005.10.007.
• [32] KIM S H,LEE J Y,PARK S H,et al. Plasma B-type natriuretic peptide level in patients with acute cerebral infarction according to infarction subtype and infarction volume[J]. Int J Med Sci,2013,10(1):103-109. DOI:10.7150/ijms.5005.