刘玲

• 1:洛阳市第一人民医院神经内科

摘要(Abstract)：

目的分析大剂量阿托伐他汀钙对急性缺血性脑卒中患者神经功能的保护作用。方法将洛阳市第一人民医院90例急性缺血性脑卒中患者以随机数表法分为大剂量组和常规组各45例,均给予阿托伐他汀钙治疗,大剂量组初始剂量40 mg/d,常规组为10 mg/d,连续治疗24周。评估2组治疗前后神经功能、生活能力,比较2组治疗前后血脂、炎症因子水平及斑块面积变化,并评估2组用药安全性。结果 2组治疗前NIHSS评分、Barthel指数评分、血脂、炎症因子水平及斑块面积比较差异无统计学意义(P>0.05),治疗2周、24周大剂量组NIHSS评分均显著低于常规组(P<0.05),Barthel指数评分显著高于常规组(P<0.05);治疗后大剂量组TC、TG、CRP水平均明显低于常规组(P<0.05),斑块面积明显小于常规组(P<0.05);2组不良反应率比较差异无统计学意义(P>0.05)。结论大剂量阿托伐他汀钙对急性缺血性脑卒中患者神经功能保护作用更显著,其作用机制可能与调节血脂、炎症因子水平及缩小斑块面积有关,对改善患者日常活动能力有重要意义。

关键词(KeyWords)： 急性缺血性脑卒中;大剂量;阿托伐他汀钙;神经功能

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘玲

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