刘景艳,录海斌

• 1:郑州市妇幼保健院儿科
• 2:河南省胸科医院神经内科

摘要(Abstract)：

目的研究HIE新生儿神经生长因子的早期干预对相关时间指标、脑损伤程度和神经行为的影响。方法分析郑州市妇幼保健院2010-12—2015-12确诊的120例缺氧缺血性脑病(hypoxic-ischemic encephalopathy,HIE)新生儿资料,按照临床干预时不同方案分成2组,将60例行胞二磷胆碱治疗患者设为对照组,将60例联合神经生长因子的早期干预患者设为观察组,对2组相关时间指标、脑损伤程度和神经行为加以对比。结果观察组肌张力、反射和意识恢复时间均比对照组短(P<0.05);观察组治疗后髓鞘碱性蛋白与酸性钙离子结合蛋白水平改善效果均较对照组优,且治疗1周、2周后神经行为功能评分(neurobehavioral function score,NBFS)(30.40±6.50)分、(32.60±6.55)分均比对照组高(P<0.05)。结论 HIE新生儿联合神经生长因子的早期干预能够缩短相关时间指标,减轻患儿脑损伤程度和提高神经行为功能。

关键词(KeyWords)： 缺氧缺血性脑病;新生儿;神经生长因子;脑损伤程度;神经行为

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 刘景艳,录海斌

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