朱洪山,朱宁,夏彬,赵伟丽,吴睿,薛孟周

• 1:郑州大学第二附属医院

摘要(Abstract)：

目的研究计算机辅助认知训练联合多奈哌齐治疗卒中后认知障碍的临床疗效。方法筛选脑卒中后轻中度血管性认知障碍的患者83例,随机分为2组。其中,对照组42例予脑卒中规范治疗并口服盐酸多奈哌齐5 mg,qd;观察组41例在上述治疗基础上应用计算机辅助认知训练,40 min/d,每周5 d。治疗前及6周后应用蒙特利尔认知测验(MoCA)评价总体认知功能;数字广度测验评估注意力及工作记忆;连线测验评估执行功能;动物流畅性测验评估语言功能;改良Barthel指数(MBI)评估患者日常生活活动能力。结果治疗6周后,观察组和对照组在MoCA评分、数字广度测验正背及倒背、连线测验B-连线测验A、言语流畅性测验、日常生活能力评分均明显改善,差异有统计学意义(P<0.01)。其中,观察组在MoCA、数字广度测验正背及倒背、言语流畅性测验、日常生活能力评分方面较对照组明显提高,差异有统计学意义(P<0.05)。结论计算机辅助认知训练联合多奈哌齐治疗卒中后认知障碍,能显著改善患者整体认知功能、注意力、工作记忆、言语能力、日常生活能力,提高患者的生活质量。

关键词(KeyWords)： 计算机辅助认知训练;多奈哌齐;脑卒中;卒中后认知障碍;蒙特利尔认知测验;执行功能;六六脑-脑康复系统;认知康复

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金面上项目(编号:81471174;81870942);国家自然科学基金重点国际(地区)合作研究项目(编号:81520108011);; 国家重点研发计划(编号:2018YFC1312200);; 河南省医学科技攻关计划项目(编号:201702076)

作者(Author): 朱洪山,朱宁,夏彬,赵伟丽,吴睿,薛孟周

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