陈茂才;

• 1:郑州大学第二附属医院检验科

摘要(Abstract)：

目的观察成人颅内感染性疾病患者脑脊液中白介素-6(interleukin-6,IL-6)、超敏C反应蛋白(high sensitive C-reactive protein,hs-CRP)、降钙素原(procalcitonin,PCT)、乳酸脱氢酶(lactic dehydrogenase,LDH)、腺苷脱氨酶(adenosine deaminase,ADA)、胆碱酯酶(cholinesterase,CHE)、谷草转氨酶(glutamic oxalacetic transaminase,AST/GOT)水平的变化,并探讨其临床意义。方法选取郑州大学第二附属医院2015-01—2018-06收治的120例患者,A组为30例化脓性脑膜炎患者,B组为28例病毒性脑膜炎患者,C组为22例结核性脑膜炎患者,D组为40例无颅内感染的患者。检测脑脊液IL-6、hs-CRP、PCT、LDH、ADA、CHE、AST水平,比较4组检测指标。结果 A、B、C组分别与D组相比,A组脑脊液hs-CRP、PCT、ADA水平明显高于D组,差异有统计学意义(P<0. 05); B组脑脊液hs-CRP、PCT、ADA水平与D组相比,差异无统计学意义(P> 0. 05); C组脑脊液ADA水平明显高于D组,差异有统计学意义(P<0. 05); PCT、hs-CRP水平与D组相比,差异无统计学意义(P> 0. 05); A、B、C组IL-6、LDH、CHE、AST水平均明显高于D组,差异有统计学意义(P<0. 05)。结论成人化脓性脑膜炎患者脑脊液中IL-6、hs-CRP、PCT、LDH、ADA、CHE、AST水平明显升高,对化脓性脑膜炎患者具有较高的早期诊断价值; ADA可作为结核性脑膜炎的鉴别诊断指标。

关键词(KeyWords)： 成人颅内感染性疾病;脑脊液;降钙素原;超敏C反应蛋白;腺苷脱氨酶;白介素6;乳酸脱氢酶;胆碱酯酶

Abstract:

Keywords:

基金项目(Foundation):

作者(Authors): 陈茂才;

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