李沛;孙萌萌;张红菊;付畅;张伟峰;李会强;徐俊玲;

• 1:河南省人民医院郑州大学人民医院

摘要(Abstract)：

目的前瞻性分析大脑静息葡萄糖代谢改变在初诊肺癌患者情绪障碍发病中的临床意义。方法实验组来自临床拟诊肺癌并拟行全身(脑+躯干)18F-氟脱氧葡萄糖(18F-FDG)正电子发射断层显像/计算机体层摄影(PET/CT)检查的患者,对照组来自健康体格检查者。所有被试者在18F-FDG PET/CT检查前接受哈密尔顿抑郁量表(HAMD)及焦虑量表(MAS)评定,对比分析大脑静息葡萄糖代谢改变、情绪障碍评分以及两者之间的相关性。结果最终纳入155例肺癌患者(实验组)及152例健康体检者(对照组),实验组HAMD评分及MAS评分均高于对照组(t=1.020.P=0.04;t=0.09,P=0.03);实验组脑PET显像存在以双侧额、颞叶为主的多个脑区葡萄糖代谢减低,且受累脑区平均标准化摄取值(SUV)在双侧额叶及左侧颞叶分别与HAMD评分呈负相关(r=0.68、 0.60、 0.55),在左侧额叶及左侧颞叶分别与MAS评分呈负相关(r=0.59、 0.58)。结论大脑静息葡萄糖代谢改变与情绪障碍在肺癌患者中具有显著相关性,且以额叶为著。脑葡萄糖代谢改变可能是肺癌患者情绪障碍发病的神经病理基础,有望作为神经生物学标记用于临床评估。

关键词(KeyWords)： 情绪障碍;肺肿瘤;脱氧葡萄糖F18;脑葡萄糖代谢;正电子发射断层显像术;抑郁量表;焦虑量表

Abstract:

Keywords:

基金项目(Foundation): 2020年度河南省医学科技攻关计划省部共建重点项目（编号：202002007）

作者(Authors): 李沛;孙萌萌;张红菊;付畅;张伟峰;李会强;徐俊玲;

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