精神分裂症患者认知功能与临床特征关系分析
李猛,朱俊敬,张淑芳,李文峰,付慧鹏
摘要(Abstract)：
目的探讨精神分裂症患者认知功能与临床特征的关系。方法采用事件相关电位(Event-related Potentials,ERP)P300和探究性眼动分析(exploratory eye movement,EEM)评估患者组及对照组的认知功能,同时采用阳性和阴性症状量表(PANSS)评定患者的精神症状。结果患者组P300潜伏期较对照组延长,波幅降低,EEM中NEF及RSS减少,D值增加,差异均具有统计学意义(P<0.01)。患者组P300潜伏期与PANSS量表一般状况分、思维障碍评分及激活性评分均呈负相关(P<0.05),波幅与PANSS量表阴性症状分及一般状况分均呈负相关(P<0.01,P<0.05);EEM中凝视点数(NEF)与阴性症状分呈负相关(P<0.05),PANSS总分与反应性探索评分(RSS)呈负相关(P<0.05),与D值呈正相关(P<0.01)。结论 P300和EEM测定可作为精神分裂症认知功能诊断的参考指标之一;阴性症状的严重程度是影响精神分裂症患者认知功能的主要因素。
关键词(KeyWords)： 精神分裂症;认知功能;临床特征;事件相关电位;探究性眼动分析
基金项目(Foundation):
作者(Author): 李猛,朱俊敬,张淑芳,李文峰,付慧鹏
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