李玉生;刘聪慧;王运超;蔚文锴;张瑶;于璐璐;赵子晨;高远;

• 1:郑州大学第一附属医院

摘要(Abstract)：

目的探讨与脑小血管病机制更为相关的远端型孤立性皮质下小梗死(dSSSI)可能较动脉粥样硬化机制的近端型皮质下小梗死(pSSSI)表现出更高的血清Hcy水平。方法所有数据均来自于郑州大学第一附属医院神经内科前瞻性登记的缺血性卒中数据库。本研究使用既往报道的标准轴面影像模板。该模板上的豆纹动脉区包含6个标准层面,第1层代表基底节区最低的部分,第6层为穿支动脉最远端的部分。DWI序列上累及第1层或第2层定义为pSSSI,累及第3层～第6层中任意一层定义为dSSSI。结果 dSSSI与血清Hcy水平独立相关,与Hcy处于最低四分位区间的患者相比,第二区间的患者影像表现为dSSSI的OR值为1.530(0.822,2.848),第三区间为2.066(1.077,3.962),最高四分位数区间为2.815(1.406,5.637)。结论与pSSSI相比,血清Hcy与dSSSI的关系更密切。在未来,通过降Hcy治疗dSSSI有效性有待进一步的临床研究。

关键词(KeyWords)： 孤立性皮质下小梗死;同型半胱氨酸;脑小血管病;动脉粥样硬化

Abstract:

Keywords:

基金项目(Foundation): 河南省科技攻关项目(编号:162102410062);; 国家重点研发计划重大慢性非传染性防控研究重点专项(编号:2017YFC1307703)

作者(Authors): 李玉生;刘聪慧;王运超;蔚文锴;张瑶;于璐璐;赵子晨;高远;

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