李素军;李伟芳;杨磊;李媛媛;

• 1:郑州大学第一附属医院

摘要(Abstract)：

目的观察舍曲林联合重复经颅磁刺激(rTMS)对老年2型糖尿病伴抑郁患者的治疗效果。方法选择2017-05—2020-08郑州大学第一附属医院老年内分泌科老年2型糖尿病伴抑郁患者120例,根据抛硬币法随机分为舍曲林联合重复经颅磁刺激组(联合组)和舍曲林单药治疗组(单药组)各60例,观察8周,联合组随访到53例,单药组随访到54例。对比2组治疗前后抗抑郁治疗有效率、汉密顿抑郁量表(HAMD-17)评分、服药依从性量表(MMAS-8)评分、中文版老年糖尿病自我管理行为量表(DSMB-O)评分和副反应量表(TESS)评分。结果治疗后2组有效率、MMSA-8、DSMB-O评分均随治疗时间的延长而增加,联合组增加幅度高于单药组,差异均有统计学意义(P<0.05)。治疗后2组HAMD-17评分均随治疗时间的延长而下降,联合组下降幅度高于单药组,差异均有统计学意义(P<0.05)。治疗后2组TESS评分差异无统计学意义(P>0.05)。结论 rTMS能够增强舍曲林对老年2型糖尿病伴抑郁患者的抗抑郁效果,同时能够增加患者的服药依从性和自我管理能力。

关键词(KeyWords)： 抑郁症;2型糖尿病;老年;重复经颅磁刺激;舍曲林

Abstract:

Keywords:

基金项目(Foundation): 河南省重大公益性项目[编号：HNZB(2010)N91号]

作者(Authors): 李素军;李伟芳;杨磊;李媛媛;

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