杜开先;高丽佳;贾天明;李林;霍爱香;李曼曼;张华玲;

• 1:郑州大学第三附属医院小儿神经内科

摘要(Abstract)：

目的探讨病毒性脑炎及化脓性脑膜炎患儿脑脊液(CSF)1-磷酸鞘氨醇(S1P)的变化。方法选取病毒性脑炎患儿30例,化脓性脑膜炎患儿30例以及非颅内感染患儿(对照组)20例,采用酶联免疫吸附试验定量测定CSF中S1P水平。结果化脑组CSF中S1P水平高于病脑组及对照组[(0.217±0.017)nmol/L vs(0.191±0.010)nmol/L、(0.172±0.015)nmol/L,P<0.05];病脑组CSF中S1P的水平高于对照组[(0.191±0.010)nmol/L vs(0.172±0.015)nmol/L,P<0.05]。结论 S1P参与儿童颅内感染发病过程,在不同病原导致的颅内感染中作用程度可能不同。

关键词(KeyWords)： 1-磷酸鞘氨醇;脑脊液;病毒性脑炎;化脓性脑膜炎;颅内感染

Abstract:

Keywords:

基金项目(Foundation): 河南省教育厅科学技术研究重点项目(13A320662)

作者(Authors): 杜开先;高丽佳;贾天明;李林;霍爱香;李曼曼;张华玲;

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