武天坤,高明,吴国学,张卫东,陈平

• 1:郑州人民医院

摘要(Abstract)：

目的研究银杏蜜环口服溶液对低频下降型突发性聋患者耳内微循环和氧化应激水平相关指标血小板聚集率(PAR)、C反应蛋白(CRP)、过氧化脂质(LPO)、一氧化氮(NO)、超氧化物歧化酶(SOD)变化的影响及临床疗效。方法选取2017-06—2019-06在郑州人民医院耳鼻咽喉头颈外科接受治疗的96例低频下降型突发性耳聋患者,随机分为对照组和治疗组,每组48例。对照组给予常规西药治疗(甲钴胺片、地塞米松注射液和长春西汀注射液);治疗组在对照组的基础上加用银杏蜜环口服溶液,疗程2周。比较2组临床疗效、伴随症状改善时间及银杏蜜环口服溶液对患者耳内微循环和氧化应激水平相关指标PAR、CRP、LPO、NO、SOD变化的影响。结果对照组和治疗组的愈显率分别为75%和91.67%,治疗后PAR降低,应激和微循环CRP、LPO水平降低,NO、SOD水平升高,差异有统计学意义(P<0.05);相对于对照组,治疗组治疗后PAR降低、CRP、LPO水平降低,NO、SOD水平升高,差异有统计学意义(P<0.05)。结论银杏蜜环口服溶液治疗低频下降型突发性聋的临床疗效确切,能较好改善患者临床伴随症状,改善机体的氧化应激水平和耳内微循环,益于患者康复,安全性高,为临床治疗突发性聋低频下降型提供了参考依据。

关键词(KeyWords)： 突发性聋;低频下降;银杏蜜环口服溶液;氧化应激;耳内微循环

Abstract:

Keywords:

基金项目(Foundation): 2018年河南省中医药科学研究专项课题（编号：2018ZY3015）

作者(Author): 武天坤,高明,吴国学,张卫东,陈平

参考文献(References)：

• [1]MARX M,YOUNES E,CHANDRASEKHAR S S,et al.International consensus(ICON)on treatment of sudden sensorineural hearing loss[J].Eur Ann otorhinolaryngol Head Neck Dis,2018,135(1S):S23-S28．
• [2]CHANDRASEKHAR S S,TSAI DO B S,SCHWARTZS R,et al.Clinical practice guideline:sudden hearing loss(update)executive summary[J].Otolaryngol Head Neck Surg,2019,161(2):195-210．
• [3]SUN C L,GUO D N,SHEN J,et al.A clinical analysis of 27 cases of simultaneous bilateral sudden sensorineural hearing loss[J].Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2019,33(12):1134-1137.DOI:10.13201/j.issn.1001-1781.2019.12.005．
• [4]PARK K V,OH K H,JEONG Y J,et al.Machine Learning Models for Predicting Hearing Prognosis in U-nilateral Idiopathic Sudden Sensorineural Hearing Loss[J].Clin Exp Otorhinolaryngol,2020 Mar 12.DOI:10.21053/ceo.2019.01858．
• [5]ZHAO K,XU Y,WANG M X,et al.Anxiety and depression in patients with sudden sensorineural hearing loss and its influencing factors[J].J Clin Otorhinolar-yngol Head Neck Surg,2017,31(22):1735-1739．
• [6]XI J,LIU H,WANG X.Prostaglandin E1 effects on CD62p and PAC-1in patients with sudden sensorineural hearing loss[J].Thromb Res,2020,188:31-38.DOI:10.1016/j.thromres.2020.01.023．
• [7]LYU Y,ZENG F,YAN M,et al.Comparison of 2Different Intratympanic Methylprednisolone Injection Schedules in Combination With Intravenous Dexamethasone for Unilateral Sudden Sensorineural Hearing Loss[J].Ear Nose Throat J,2020Feb 19:145561320904816.DOI:10.1177/0145561320904816．
• [8]YOUNG Y H.Contemporary review of the causes and differential diagnosis of sudden sensorineural hearing loss[J].Int J Audiol,2019 Nov 12.DOI:10.1080/14992027.2019.168943．
• [9]CHEN S,ZHAO M,QIU J.Acupuncture for the treatment of sudden sensorineural hearing loss:A systematic review and meta-analysis:Acupuncture for SSNHL[J].Complement Ther Med,2019,42:381-388.DOI:10.1016/j.ctim.2018.12.009．
• [10]LI J,DING L.Effectiveness of Steroid Treatment for Sudden Sensorineural Hearing Loss:A Meta-analysis of Randomized Controlled Trials[J].Ann Pharmacother,2020 Mar 4:1060028020908067.DOI:10.1177/1060028020908067．
• [11]CHOI Y,CHOI H L,JEONG A Y,et al.Hyperbaric oxygen(HBO)therapy as an effective approach to the treatment of patients with severe idiopathic sudden sensorineural hearing loss[J].Acta Otolaryngol,2020Feb 12:1-4.DOI:10.1080/00016489.2020.1717607．
• [12]WU S,CAO Z,SHI F,et al.Investigation of the prognostic role of neutrophil-to-lymphocyte ratio in Idiopathic Sudden Sensorineural Hearing Loss based on propensity score matching:a retrospective observational study[J].Eur Arch Otorhinolaryngol,2020 Mar 13.DOI:10.1007/s00405-020-05905-z．
• [13]MARUYAMA A,KAWASHIMA Y,FUJIKAWA T,et al.Potential Confounding Factors May Influence the Association Between Configurations of the Vertebrobasilar System and the Incidence of Idiopathic Sudden Sensorineural Hearing Loss and Canal Paresis[J].Otol Neurotol,2020 Mar 6.DOI:10.1097/MAO.0000000000002605．
• [14]LIU Y,CHEN Q,XU Y.Research progress in refractory sudden hearing loss:steroid therapy[J].J Int Med Res,2020,48(1):300060519889426.DOI:10.1177/0300060519889426．
• [15]WANG S,YE Q,PAN Y.Serum non-high-density lipoprotein cholesterol is associated with the risk of sudden sensorineural hearing loss[J].Medicine(Baltimore),2020,99(7):e19175.DOI:10.1097/MD.0000000000019175．
• [16]MIRIAN C,OVESEN T.Intratympanic vs Systemic Corticosteroids in First-line Treatment of Idiopathic Sudden Sensorineural Hearing Loss:A Systematic Review and Meta-analysis[J].JAMA Otolaryngol Head Neck Surg,2020 Mar 12.DOI:10.1001/jamaoto.2020.0047．
• [17]SEO H W,CHUNG J H,BYUN H,et al.Effect of Diabetes on the Prognosis of Sudden Sensorineural Hearing Loss:Propensity Score Matching Analysis[J].Otolaryngol Head Neck Surg,2020,162(3):346-352.DOI:10.1177/0194599820901359．
• [18]INUI H,SAKAMOTO T,ITO T,et al.Magnetic resonance imaging of endolymphatic space in patients with sensorineural hearing loss:comparison between fluctuating and idiopathic sudden sensorineural hearing loss[J].Acta Otolaryngol,2020Feb 6:1-6.DOI:10.1080/00016489.2020.1720919．
• [19]OJHA S,HENDERSON A,BENNETT W,et al.Sudden sensorineural hearing loss and bedside phone testing:aguide for primary care[J].Br J Gen Pract,2020,70(692):144-145.DOI:10.3399/bjgp20X708761．
• [20]WANG S,YE Q,PAN Y,et al.Serum non-high-density lipoprotein cholesterol is associated with the risk of sudden sensorineural hearing loss[J].Medicine(Baltimore),2020,99(7):e19175.DOI:10.1097/MD.0000000000019175．
• [21]HE H,YUAN K,CHEN W,et al.Effect of tympanic dexamethasone injection in the treatment of different types of sudden deafness[J].Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi,2020,34(2):124-127.DOI:10.13201/j.issn.1001-1781.2020.02.006．
• [22]PECORARI G,RIVA G,BRUNO G,et al.Recurrences in Sudden Sensorineural Hearing Loss:A Long-Term Observational Study[J].Am J Audiol,2020,29(1):18-22.DOI:10.1044/2019_AJA-19-00061.