罗雅婷,刘雪梅

• 1:信阳市中心医院检验科
• 2:信阳市职业技术学院附属医院检验科

摘要(Abstract)：

目的探析血管内皮素-1(ET-1)与血清尿酸(UA)在轻度认知障碍(MCI)患者中的检测价值。方法分析2013-01—2016-11信阳市中心医院院及信阳市职业技术学院附属医院诊治的74例MCI患者的临床资料。根据MCI患者的临床症状分成A组(单纯记忆障碍,无其他认知障碍,32例)和B组(记忆障碍合并其他认知功能障碍,42例)2组。另外选取同期接受健康体检的76例正常健康者作为本次研究的对照组。比较MCI组与对照组的基线资料、血清UA与ET-1水平,比较A、B 2组患者的血清UA与ET-1水平。多因素Logistic回归分析MCI的危险因子。结果 MCI组与对照组的基线资料无显著性差异(P>0.05)。MCI组患者的血清UA水平明显低于对照组,ET-1水平明显高于对照组(P<0.01);A组患者血清UA明显高于B组(P<0.01),ET-1水平与B组相比差异无统计学意义(P>0.05)。年龄、血压、血糖、UA、ET-1、TC、LDL-C是MCI患者的独立危险因子。结论高ET-1、低UA水平均是MCI患者发病的独立危险因子,检测ET-1与UA水平在MCI患者中具有重要的临床价值。

关键词(KeyWords)： 轻度认知障碍;血管内皮素-1;尿酸;记忆障碍;阿尔茨海默病

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 罗雅婷,刘雪梅

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