宋婕,张玉佩,马宁

• 1:中国人民解放军总医院第七医学中心儿科研究所

摘要(Abstract)：

目的 探讨血清吲哚丙酸（IPA）、同型半胱氨酸（Hcy）联合25-羟基维生素D[25(OH)D]对高血压并发脑梗死的诊断价值。方法 选取2022-06—2023-08中国人民解放军总医院第七医学中心的高血压患者102例，根据头颅CT或MRI检查结果将41例高血压并发脑梗死患者纳入并发组，61例高血压未并发脑梗死患者纳入未并发组。收集高血压患者临床资料，Logistic回归分析高血压患者发生脑梗死的影响因素，采用受试者工作特征（ROC）曲线分析IPA、Hcy、25(OH)D对高血压并发脑梗死的诊断价值。结果 并发组年龄、吸烟史占比、收缩压及LDL-C、WBC、Hcy水平高于未并发组，PLT、IPA、25(OH)D水平低于未并发组（P<0.05）。Logistic回归分析显示，年龄、吸烟史、收缩压及LDL-C、WBC、IPA、Hcy、PLT、25(OH)D是高血压并发脑梗死的影响因素（P<0.05）。IPA、Hcy、25(OH)D联合诊断的AUC值0.935,95%CI:0.868～0.974，敏感度85.37%，特异度91.80%，优于各指标单独诊断（P<0.05）。结论 血清IPA、Hcy、25(OH)D与高血压患者脑梗死的发生密切相关，三者联合检测有助于提高高血压并发脑梗死的诊断效能。

关键词(KeyWords)： 高血压;脑梗死;吲哚丙酸;同型半胱氨酸;25-羟基维生素D;诊断效能

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 宋婕,张玉佩,马宁

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