阿托伐他汀对脑组织血红素加氧酶的影响Effect of atorvastatin on heme oxygenase in brain tissues
王冰;王江桥;
摘要(Abstract)：
目的研究阿托伐他汀对β淀粉样蛋白1-42诱导阿尔茨海默病大鼠模型大脑顶叶皮层和小脑血红素加氧酶(HO)的影响。方法将40只Wistar大鼠随机分为正常对照组、他汀对照组、模型对照组和他汀治疗组,每组10只。Western blot法检测顶叶皮层和小脑HO-1和HO-2的表达。结果顶叶皮层区他汀治疗组HO-1的表达增加与其他3组相比差异有统计学意义(P<0.05),而4组HO-2的表达相比差异无统计学意义(P>0.05);小脑区他汀治疗组HO-2的表达增加与其他3组相比差异有统计学意义(P<0.05),而4组HO-1的表达相比差异无统计学意义(P>0.05)。结论阿托伐他汀可以上调大脑不同部位HO-1和HO-2的表达,减轻神经细胞损伤。
关键词(KeyWords)： 阿尔茨海默病;阿托伐他汀;血红素加氧酶
基金项目(Foundation):
作者(Authors): 王冰;王江桥;
参考文献(References)：
- [1]Chopra K,Misra S,Kuhad A,et al.Current perspectives on pharmacotherapy of Alzheimer's disease[J].Expert Opinion Pharmacotherapy,2011,12(3):335-350.
- [2]Kandiah N,Feldman HH.Therapeutic potential of statins in Alzheimer's disease[J].J Neurol Sci,2009,283(1-2):230-234.
- [3]Mancuso C,Barone E.The heme oxygenase/biliverdin reductase pathway in drug research and development[J].Curr Drug Metabo,2009,10(6):579-594.
- [4]Christou H,Bailey N,Kluger MS,et al.Extra-cellular acidosis induces heme oxygenase-1 expression in vascular smooth muscle cells[J].Am J Physiol Heart Cire Phsiol,2005,288(6):2 647-2 652.
- [5]Butterfield DA,Lauderback CM.Lipid peroxidation and protein oxidation in Alzheimer's disease brain:potential causes and consequences involving amyloid beta-peptideassociated free radical oxidative stress[J].Free Radic Biolo a Medi,2002,32(11):1 050-1 060.
- [6]Barone E,Cenini G,DiDomenico F,et al.Long-term high-dose atorvastatin decreases brain oxidative and nitrosative stress in a preclinical model of Alzheimer disease:a novel mechanism of action[J].Pharmacol Res,2011,63(3):172-180.
- [7]Kinderlerer AR,Gregoire IP,Hamdulay SS.Heme oxygenase-1expression enhances vascular endothelial resistance to complement-mediated injury through induction of decay-accelerating factor[J].A role for increased bilirubin and ferritin.Blood,2009,113(7):1 598-1 607.