饶克成;李明;高飞;蔡春雨;

• 1:南阳市第二人民医院神经外科
• 2:郑州大学人民医院神经外科

摘要(Abstract)：

目的探讨早期高压氧对重型颅脑损伤术后患者血清TNF?α、IL-6及肢体运动功能的影响。方法选取南阳市第二人民医院2012-06—2015-06收治的75例重型颅脑损伤患者,所有患者给予开颅去骨瓣减压术,随机分为观察组(n=38)与对照组(n=37),术后给予常规治疗,观察组给予早期高压氧治疗。术前及术后第1、3、7天采用酶联免疫吸附法检测血清TNF?α、IL-6含量;术前及术后3个月采用Fugl-Meyer评分评定肢体运动功能。结果术前2组血清TNF?α、IL-6含量比较,差异均无统计学意义(P>0.05);2组术后血清TNF?α、IL-6含量逐渐升高,第3天时达最高峰,后逐渐降低;观察组术后第1、3、7天血清TNF?α、IL-6含量均明显低于同期对照组,差异均有统计学意义(P<0.05)。术前2组Fugl-Meyer评分差异无统计学意义(P>0.05),术后3个月观察组Fugl-Meyer评分明显高于对照组,差异有统计学意义(P<0.05)。结论高压氧疗法可有效降低重型颅脑损伤患者的颅内压,减轻炎症反应,改善脑组织的微循环和有氧代谢,提高肢体运动功能。

关键词(KeyWords)： 重型颅脑损伤;高压氧疗法;TNF-α;IL-6;血清;Fugl-Meyer评分

Abstract:

Keywords:

基金项目(Foundation): 国家自然科学基金(81372405;81172415)

作者(Authors): 饶克成;李明;高飞;蔡春雨;

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