李刚;胡亚梅;刘建锋;张红菊;向莉;侯亚辉;靳培军;罗之云;

• 1:河南省人民医院暨郑州大学人民医院神经内科

摘要(Abstract)：

目的研究阻塞性睡眠呼吸暂停综合征(OSAHS)患者血清脂质运载蛋白2(LCN-2)、脂素蛋白1(Lipin1)水平和胰岛素抵抗的关系。方法根据睡眠呼吸监测数据,将患者分为轻度OSAHS组、中度OSAHS组、重度OSAHS组和正常对照组,检测并比较各组血清LCN-2、Lipin1和胰岛素抵抗指数(HOMA-IR)等生化指标,并研究其相关性。结果重度OSAHS组、中度OSAHS组患者较正常对照组血清LCN-2和HOMA-IR升高、Lipin1降低,差异有统计学意义(P<0.05);重度OSAHS组较轻度OSAHS组LCN-2和HOMA-IR升高、Lipin1降低,差异有统计学意义(P<0.05);LCN-2与BMI、LDL-C、HOMA-IR呈正相关;Lipin1与BMI、LDL-C、HOMA-IR呈负相关;多元线性相关分析示AHI与腰围、HOMA-IR、LCN-2和Lipin1有线性回归关系,其中与Lipin1负相关。结论 OSAHS患者可能通过升高LCN-2及降低Lipin1引起胰岛素抵抗。

关键词(KeyWords)： 阻塞性睡眠呼吸暂停综合征;脂质运载蛋白2;脂素蛋白1;胰岛素抵抗

Abstract:

Keywords:

基金项目(Foundation): 郑州市金水区科技攻关项目(2013)26号

作者(Authors): 李刚;胡亚梅;刘建锋;张红菊;向莉;侯亚辉;靳培军;罗之云;

参考文献(References)：

• [1]Chan YK,Sung HK,Jahng JW,et al.Lipocalin-2inhibits autophagy and induces insulin resistance in H9c2cells[J].Mol Cell Endocrinol,2016,430:68-76.
• [2]Law IK,Xu A,Lam KS,et al.Lipocalin-2deficiency attenuates insulin resistance associated with aging and obesity[J].Diabetes,2010,59(4):872-882.
• [3]Kamble PG,Pereira MJ,Sidibeh CO,et al,Lipocalin 2produces insulin resistance and can be upregulated by glucocorticoids in human adipose tissue[J].Mol Cell Endocrinol,2016,427:124-132.
• [4]Phan J,Reue K.Lipin,a lipodystrophy and obesity gene[J].Cell Metab,2005,l(1):73-83.
• [5]Loos RJ,Rankinen T,Pérusse L,et al.Bouchard C.Association of lipin 1gene polymorphisms with measures of energy and glucose metabolism[J].Obesity,2007,15(11):2 723-2 732.
• [6]van Harmelen V,Rydén M,Sj9lin E,et al.A role of lipin in human obesity and insulin resistance:relation to adipocyte glucose transport and GLUT4expression[J].J Lipid Res,2007,48(1):201-206.
• [7]Mlinar B,Pfeifer M,Vrtacnik Bokal E,et al.Decreased lipin 1{beta}expression in visceral adipose tissue is associated with insulin resistance in polycystic ovary syndrome[J].Eur J Endocrinol,2008,159(6):833-839.
• [8]van Harmelen V,Rydén M,Sj9lin E,et al.A role of lipin in human obesity and insulin resistance:relation to adipocyte glucose transport and GLUT4expression[J].J Lipid Res.2007,48(1):201-206.