张碧月;陈雅芳;黄银辉;

• 1:福建医科大学附属第二医院神经内科
• 2:晋江市医院神经内科

摘要(Abstract)：

目的探讨阿米替林联合丙戊酸钠治疗药物过度使用性头痛的疗效。方法选取药物过度使用性头痛(medication overuse headache,MOH)患者,进行健康教育,建议停用各种止痛剂,并按照随机数字表分为治疗组和对照组,其中治疗组给予阿米替林+丙戊酸钠缓释片治疗(每晚口服阿米替林25mg+丙戊酸钠缓释片500mg),对照组仅予丙戊酸钠缓释片治疗(每晚口服丙戊酸钠缓释片500mg),疗程3个月。记录并比较2组患者头痛发作频率、头痛严重程度及药物不良反应发生情况。结果阿米替林联合丙戊酸钠治疗组,患者头痛发作频率、头痛严重程度显效改善率高于对照组(68.42%vs 25.00%,P<0.05),治疗组总体有效率明显高于对照组(89.47%vs 55.00%,P<0.05)。治疗组与对照组不良反应发生率无明显差别(10.52%vs 7.50%,P<0.05)。结论阿米替林联合丙戊酸钠治疗药物过度使用性头痛安全有效。

关键词(KeyWords)： 药物过度使用性头痛(MOH);阿米替林;丙戊酸钠;头痛严重程度(VAS评分);头痛致残程度(MIDAS评分)

Abstract:

Keywords:

基金项目(Foundation): 晋江市科技计划项目,编号201514001

作者(Authors): 张碧月;陈雅芳;黄银辉;

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