神经生长因子治疗早产儿脑病的疗效观察
冯晓霞,宋红,宋焕清,李倩,刘园园,周川
摘要(Abstract)：
目的观察神经生长因子(never growth factor,NGF)治疗早产儿脑病的疗效。方法将确诊早产儿脑病的60例患儿随机分为2组:对照组29例,NGF干预组31例。2组患儿均给予常规治疗,干预组在常规治疗基础上给予NGF肌注治疗,1支/d,14d为1个疗程。治疗前和1月时行头颅磁共振检查及新生儿行为神经评分(NBNA),分别于患儿生后3个月、6个月和12个月时采用智力发育指数(MDI)和运动发育指数(PDI)进行评估。结果 NGF干预组头颅磁共振检查所示脑结构的恢复及NBNA评分,MDI、PDI均明显优于对照组(P<0.05)。结论早期应用神经生长因子治疗早产儿脑病能改善患儿的智力和运动发育水平,降低神经系统后遗症的发生率。
关键词(KeyWords)： 早产儿脑病;神经生长因子;新生儿
基金项目(Foundation):
作者(Author): 冯晓霞,宋红,宋焕清,李倩,刘园园,周川
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