王运良,曾志磊,尹红蕾,韩冰,张辉,刘亚军,娄季宇

• 1:解放军第一四八中心医院神经内科
• 2:郑州大学第二附属医院神经内科

摘要(Abstract)：

目的探讨动脉瘤性蛛网膜下腔出血(SAH)血管内栓塞后D-dimer浓度的变化以及D-dimer浓度升高能否做为预后不良的独立预测因素。方法对204例发病48 h内入住我院和郑州大学第二附属医院神经内科的SAH病人,在手术当天早晨和动脉瘤填塞后14 d检测血浆D-dimer浓度,3个月时根据格拉斯哥预后评分和CT随访脑梗塞的发生做为预后不良的预测因素。结果动脉瘤栓塞后预后不良的病人较预后良好者D-dimer浓度明显升高,手术当天2组各自平均为(1 368±298)μg/L和(756±144)μg/L,14 d时分别为(1 129±166)μg/L和(356±73)μg/L,P<0.001。重复检测发现,预后良好者D-dimer浓度降低较快,排除其他影响因素后,D-dimer与预后不良有明显关系。结论 SAH后血浆D-dimer升高是预后不良的独立预测因素,可能与凝血酶代谢产物过量积聚引起的损害有关。

关键词(KeyWords)： 动脉瘤;蛛网膜下腔出血;D-二聚体;纤维蛋白溶解

Abstract:

Keywords:

基金项目(Foundation):

作者(Author): 王运良,曾志磊,尹红蕾,韩冰,张辉,刘亚军,娄季宇

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