孙立军,刘晨,李智文,卢金华

• 1:福建医科大学附属第一医院

摘要(Abstract)：

目的研究依达拉奉对大鼠脑梗死溶栓治疗后脑组织中MMP-9表达及血脑屏障的影响,探讨依达拉奉对脑梗死溶栓治疗后再灌注损伤的保护机制。方法采用SD大鼠自体血栓栓塞法制备大脑中动脉闭塞模型,并将SD大鼠随机分为假手术组、尿激酶溶栓治疗组(UK)、尿激酶+依达拉奉治疗组(UK+ED),12h后分别以免疫组织化学法和比色法对SD大鼠脑组织中MMP-9表达水平和伊文思蓝含量进行测定。结果与尿激酶溶栓治疗组相比,尿激酶+依达拉奉组SD大鼠缺血侧脑组织MMP-9表达水平和EB含量均显著降低,差异具有统计学意义(P值均<0.01)。结论依达拉奉可能通过下调MMP-9表达,减轻血脑屏障的破坏,减轻溶栓后脑缺血再灌注损伤。

关键词(KeyWords)： 脑梗死;尿激酶;依达拉奉;MMP-9

Abstract:

Keywords:

基金项目(Foundation): 福建医科大学教授学术发展基金资助项目(NO.JS06050);; 福建省教育厅科技项目基金项目(NO.JB06256)

作者(Author): 孙立军,刘晨,李智文,卢金华

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