多发性硬化病人血清和脑脊液壳三糖苷酶活性的研究Study of chitotriosidase activity in serum and cerebrospinal fluid in multiple sclerosis patients
王运良,张玉镇,耿同超,张晓席,曾志磊,韩冰,尹红蕾
摘要(Abstract)：
目的探讨多发性硬化(MS)病人血清和脑脊液(CSF)壳三糖苷酶(CTTS)活性以及CSF免疫活化和炎症标志物。方法选择三所医院178例MS病人,其中复发缓解型MS(RRMS)120例,继发进展型MS(SPMS)32例,原发进展型MS(PPMS)26例,并选取40例其他神经疾患(OND)和30非神经疾患病人作为对照组,检测血清和CSF中CTTS活性及CSF单核细胞数(MNC)和鞘内IgG产物。结果 MS病人与OND组和对照组比较,CSF中CTTS活性明显升高,但血清不升高。RRMS和SPMS组CTTS指数高于对照组,但PPMS组正常。在伴有MNC升高或CSF寡克隆IgG区带的MS病人,CTTS指数高于无此表现者。结论 RRMS和SPMS病人CCTS指数升高,CCTS指数与CSF炎症或免疫活化标志物有关。
关键词(KeyWords)： 多发性硬化;脑脊液;血清;壳三糖苷酶;免疫球蛋白
基金项目(Foundation):
作者(Author): 王运良,张玉镇,耿同超,张晓席,曾志磊,韩冰,尹红蕾
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