PPARγ激动剂对脑缺血再灌注损伤保护作用的研究进展
孙军,刘开祥
摘要(Abstract)：
缺血性脑血管病是一种严重影响人类健康的常见病。除溶栓治疗外,目前缺血性脑血管病的其他治疗方法已经被证明都不理想。因此,不断探索新的有效防治脑血管病的方法极为重要。目前,研究证明过氧化物酶体增殖受体γ(per-oxisome proliferators activated receptor gamma,PPARγ)激动剂对脑缺血再灌注损伤具有保护作用。本文在此做一综述,对PPARγ激动剂保护作用的可能机制及研究方向进行初步探讨。
关键词(KeyWords)： PPARγ激动剂;脑缺血再灌注损伤;脑梗死
基金项目(Foundation):
作者(Author): 孙军,刘开祥
参考文献(References)：
- [1]Semple RK,Chatterjee VK,O’Rahilly S.PPAR gamma andhuman metabolic disease[J].J Clin Invest,2006,116(3):581-589.
- [2]Moreno S,Farioli-Vecchioli S,Ceru MP.Immunolocalizationof peroxisome proliferators activated receptors and retinoid re-ceptors in the adult rat CNS[J].Neuroscience,2004,123(1):131-145.
- [3]Cho MC,Lee K,Paik SG,et al.Peroxisome proliferators-Ac-tivated receptor(PPAR)modulators and metabolic disorders[J].PPAR Res,2008,20(8):67-137.
- [4]Lipton P.Ischemic cell death in brain neurons[J].Physiol,1999,79:1 431-1 568.
- [5]Danton GH,Dietrich WD.Inflammator mechanisms after is-chemia and stroke[J].J Neuro Pathol Exp Neurol,2003,62(2):127-136.
- [6]Lee J,Reding M.Effector of Thiazolidinediones on stroke re-covery:A case-matched controlled study[J].Neurochem,2006,20(8):2 375-2 377.
- [7]Di Z,Tian Y,Ma H,et al.Expression of peroxisome prolifer-ator-activated receptor gamma in hippocampus neurons in ratsafter oxygen deprivation/oxygen supply in vitro[J].ZhongNan Da Xue Xue Bao Yi Xue Ban,2009,34(12):1 238-1 242.
- [8]刘尊敬,杨期东,刘运海.PPARγ激活剂对大鼠缺血再灌注脑组织的保护作用及对PPARγ表达的影响[J].J Apoplexy andNervous Diseases,2007,124(2):132-135.
- [9]Kaundal RK,Sharma SS.GW1929:a nonthiazolidinedione P-PARγagonist,ameliorates neurological damage in global cere-bral ischemic-reperfusion injury through reduction in inflamma-tion and DNA fragmentation[J].Behav Brain Res,2011,216(2):606-12.
- [10]郭金涛,高甜,宋颖飞.PPARγ激动剂对大鼠局灶性脑缺血再灌注损伤后IL-1I、L-6和TNF-α含量的影响[J].中国实用神经疾病杂志,2008,11(2):20-22.
- [11]李正仪,郭金涛,李志伟.PPARγ激动剂对大鼠局灶性脑缺血再灌注损伤的保护作用[J].Stroke and Nervous Diseases,2006,13(5):262-278.
- [12]Shimazu T,Inoue I,Asano Y,et al.A peroxisome prolifera-tor-activated receptor-gamma agonist reduces infarct size intransient but not in permanent ischemia[J].Stroke,2005,36(2):353-359.
- [13]Li M,Pascual G,Glass CK.Peroxisome proliferator-activatedreceptor gamma-dependent repression of the inducible nitricoxide synthase gene[J].Mol Cell Biol,2000,20:4 699-4 707.
- [14]Park EJ,Park SY,Jou EH,et al.15 d-PGJ2 and rosiglita-zone suppress Januskinase-STAT inflammatory signalingthrough induction of suppressor of cytokine signaling1(SOCS1)and SOCS3 in glia[J].Biol,2003,278:14 747-14752.
- [15]Ji S,Kronenberg G,Balkaya M,et al.Acute neuroprotectionby pioglitazone after mild brain ischemia without effect onlong-term outcome[J].Exp Neurol,2009,216(2):321-328.