脑皮质下小血管病变与脑萎缩的相关性分析Discussion on the association between cerebral subcortical small-vessel disease and brain atrophy
葛海洋
摘要(Abstract):
目的探讨脑皮质下小血管病变与脑萎缩的相关性。方法通过10例临床确诊为脑萎缩的病人的调查,收集其临床基本资料及头颅磁共振成像(magnetic resonance imaging,MRI)的结果及图像,评判其脑皮质下小血管的病变情况。结果所有病例颅脑MRI均发现显著的弥漫性脑白质病变(white matter lesions,WML)和多发的脑腔隙性梗死灶(lacunarinfarcts,LI)。结论颅脑MRI提示,脑皮质下小血管病变与脑萎缩共存,提供了其与脑萎缩可能有关的临床依据。
关键词(KeyWords): 脑萎缩;白质病变;腔隙性梗死
基金项目(Foundation):
作者(Author): 葛海洋
参考文献(References):
- [1]Appel man AP,Exalto L,Biessels G,et al.White matter le-sions and brain atrophy:More than shared riskfactorsAsys-tematic review[J].Cerebrovasc Dis,2009,28:227-242.
- [2]Appel man AP,Vincken KL,Graaf Y,et al.White matter le-sions and lacunar infarcts are independently and differently as-sociated with brain atrophy:The SMART-MR Study[J].Cere-brovasc Dis,2010,29:28-35.
- [3]张俊新,田若文.局限性皮层脑萎缩67例临床分析[J].中国实用神经疾病杂志,2009,12(13):64-65.
- [4]Du AT,Schuff N,Chao LL,et al.White matter lesions areassociated with cortical atrophy more than entorhinal and hipp-ocampal atrophy[J].Neurobiology of Aging,2005,26:553-559.
- [5]赵欣春,黄岚.老年性血管性痴呆与脑白质疏松的相关研究[J].临床神经病学杂志,2003,16(4):208-209.